Symmetrical Heterocyclic Cage Skeleton: Synthesis, Urease Inhibition Activity, Kinetic Mechanistic Insight, and Molecular Docking Analyses.
Canavalia
/ enzymology
Coordination Complexes
/ chemical synthesis
Copper
/ chemistry
Enzyme Inhibitors
/ chemical synthesis
Inhibitory Concentration 50
Kinetics
Models, Molecular
Molecular Docking Simulation
Nickel
/ chemistry
Palladium
/ chemistry
Plant Proteins
/ chemistry
Structure-Activity Relationship
Triazoles
/ chemical synthesis
Urease
/ antagonists & inhibitors
heterocyclic cage
lineweaver–burk plot
metal complexes
molecular docking
urease inhibition
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
16 Jan 2019
16 Jan 2019
Historique:
received:
07
12
2018
revised:
08
01
2019
accepted:
10
01
2019
entrez:
19
1
2019
pubmed:
19
1
2019
medline:
4
4
2019
Statut:
epublish
Résumé
The present study focuses on the design and synthesis of a cage-like organic skeleton containing two triazole rings jointed via imine linkage. These molecules can act as urease inhibitors. The in-vitro urease inhibition screening results showed that the combination of the two triazole skeleton in the cage-like morphology exhibited comparable urease inhibition activity to that of the reference thiourea while the metallic complexation, especially with copper, nickel, and palladium, showed excellent activity results with IC
Identifiants
pubmed: 30654516
pii: molecules24020312
doi: 10.3390/molecules24020312
pmc: PMC6359172
pii:
doi:
Substances chimiques
Coordination Complexes
0
Enzyme Inhibitors
0
Plant Proteins
0
Triazoles
0
Palladium
5TWQ1V240M
Copper
789U1901C5
Nickel
7OV03QG267
Urease
EC 3.5.1.5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Natural Science Foundation of China
ID : 31300603
Organisme : Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
ID : No.2012-28
Organisme : The National College Student Innovation Experiment Program
ID : 14T10501
Organisme : Fundamental Research Funds for the Central Universities
ID : 15D110508, 15D110527, 15D110527, 13D110522, 17D210502, 17D310512, 18D210501, 18D310507, 2232014D3-39
Organisme : General Financial Grant from the China Postdoctoral Science Foundation
ID : 2015M571455
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