Phylogeny and evolution of infectious bursal disease virus circulating in Turkish broiler flocks.
Animals
Birnaviridae Infections
/ epidemiology
Chickens
Evolution, Molecular
Infectious bursal disease virus
/ genetics
Molecular Epidemiology
Phylogeny
Poultry Diseases
/ epidemiology
RNA, Viral
/ genetics
Sequence Analysis, RNA
/ veterinary
Turkey
/ epidemiology
Viral Structural Proteins
/ genetics
Gumboro
VP2-gene
chicken
phylogenetic
virus
Journal
Poultry science
ISSN: 1525-3171
Titre abrégé: Poult Sci
Pays: England
ID NLM: 0401150
Informations de publication
Date de publication:
01 May 2019
01 May 2019
Historique:
received:
11
09
2018
accepted:
28
11
2018
pubmed:
23
1
2019
medline:
20
4
2019
entrez:
23
1
2019
Statut:
ppublish
Résumé
The emergence of new infectious bursal disease virus (IBDV) variants can threaten poultry health and production all over the world causing significant economic losses. Therefore, this study was performed to determine IBDV molecular epidemilogy, VP2 gene variation, and corresponding pathological lesions in IBDV infected chickens in Turkey. For this, 1855 bursa of Fabricius samples were collected from 371 vaccinated broiler flocks. Atrophia and haemorrhages were seen in the bursa Fabricius of very virulent IBDV (vvIBDV) infected chickens. Partial VP2 gene was sequenced and phylogenetic, recombination, and evolutionary analyses were performed. 1548 (83.5%) out of 1855 of bursa of Fabricius samples were IBDV positive and 1525 of those could be sequenced. The recombination analysis did not detect occurrence of any recombination event among the Turkish strains. Among 1525 sequenced samples, 1380 of them were found to be classical strains. Among 1380 classical strains, 1317 were similar to IBDV 2512, 11 to Faragher 52/70, 40 to 228 E, and 12 to Lukert strain. Out of 1525 reverse transcriptase ploymerase chain reaction positive samples, 144 of them were found to be similar to vvIBDV-VP2 gene reported to GenBank previously. The phylogenetic tree performed on a broad sequence dataset demonstrated grouping of vvIBDV Turkish strains in three different clusters, including sequences collected also from Iraq and Kuwait (Cluster 1), Indian (Cluster 2), and a distinct Turkish-only cluster (Cluster 3). The evolutionary rate estimation on branches/clades including Turkish strain mirrored the expected one for RNA viruses and no significant differences were found among different considered branches. In conclusion, results of this study indicate that vvIBDV strains similar to those circulating in various countries in the Middle East are present and undergoing evolution in chickens from Turkish broiler flocks. This point needs to be taken into account in planning adequate control strategies.
Identifiants
pubmed: 30668778
pii: S0032-5791(19)30045-8
doi: 10.3382/ps/pey551
pmc: PMC6448131
doi:
Substances chimiques
RNA, Viral
0
VP2 protein, infectious bursal disease virus
0
Viral Structural Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1976-1984Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of Poultry Science Association.
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