Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium.
Africa
Africa, Western
Animals
Base Sequence
/ genetics
Cattle
Chromosome Mapping
/ methods
DNA
/ genetics
Genome
/ genetics
Genome, Mitochondrial
/ genetics
Hybridization, Genetic
/ genetics
Middle East
Phylogeny
Proteome
/ genetics
Schistosoma
/ genetics
Species Specificity
Trematoda
/ genetics
Whole Genome Sequencing
/ methods
Journal
PLoS pathogens
ISSN: 1553-7374
Titre abrégé: PLoS Pathog
Pays: United States
ID NLM: 101238921
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
05
06
2018
accepted:
07
12
2018
revised:
04
02
2019
pubmed:
24
1
2019
medline:
19
3
2019
entrez:
24
1
2019
Statut:
epublish
Résumé
Mesenteric infection by the parasitic blood fluke Schistosoma bovis is a common veterinary problem in Africa and the Middle East and occasionally in the Mediterranean Region. The species also has the ability to form interspecific hybrids with the human parasite S. haematobium with natural hybridisation observed in West Africa, presenting possible zoonotic transmission. Additionally, this exchange of alleles between species may dramatically influence disease dynamics and parasite evolution. We have generated a 374 Mb assembly of the S. bovis genome using Illumina and PacBio-based technologies. Despite infecting different hosts and organs, the genome sequences of S. bovis and S. haematobium appeared strikingly similar with 97% sequence identity. The two species share 98% of protein-coding genes, with an average sequence identity of 97.3% at the amino acid level. Genome comparison identified large continuous parts of the genome (up to several 100 kb) showing almost 100% sequence identity between S. bovis and S. haematobium. It is unlikely that this is a result of genome conservation and provides further evidence of natural interspecific hybridization between S. bovis and S. haematobium. Our results suggest that foreign DNA obtained by interspecific hybridization was maintained in the population through multiple meiosis cycles and that hybrids were sexually reproductive, producing viable offspring. The S. bovis genome assembly forms a highly valuable resource for studying schistosome evolution and exploring genetic regions that are associated with species-specific phenotypic traits.
Identifiants
pubmed: 30673782
doi: 10.1371/journal.ppat.1007513
pii: PPATHOGENS-D-18-01153
pmc: PMC6361461
doi:
Substances chimiques
Proteome
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1007513Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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