Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons.
Amino Acid Transport Systems, Acidic
/ metabolism
Animals
Axons
/ metabolism
Dopaminergic Neurons
/ metabolism
Dorsal Raphe Nucleus
/ metabolism
Glutamic Acid
/ metabolism
Male
Mice, Inbred C57BL
Nucleus Accumbens
/ metabolism
Reward
Serotonin
/ metabolism
Synapses
/ physiology
Ventral Tegmental Area
/ metabolism
VGluT3
dorsal raphe nucleus
reward
serotonin
ventral tegmental area
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
29 01 2019
29 01 2019
Historique:
received:
27
06
2018
revised:
12
10
2018
accepted:
03
01
2019
entrez:
31
1
2019
pubmed:
31
1
2019
medline:
14
3
2020
Statut:
ppublish
Résumé
Dorsal raphe (DR) serotonin neurons provide a major input to the ventral tegmental area (VTA). Here, we show that DR serotonin transporter (SERT) neurons establish both asymmetric and symmetric synapses on VTA dopamine neurons, but most of these synapses are asymmetric. Moreover, the DR-SERT terminals making asymmetric synapses on VTA dopamine neurons coexpress vesicular glutamate transporter 3 (VGluT3; transporter for accumulation of glutamate for its synaptic release), suggesting the excitatory nature of these synapses. VTA photoactivation of DR-SERT fibers promotes conditioned place preference, elicits excitatory currents on mesoaccumbens dopamine neurons, increases their firing, and evokes dopamine release in nucleus accumbens. These effects are blocked by VTA inactivation of glutamate and serotonin receptors, supporting the idea of glutamate release in VTA from dual DR SERT-VGluT3 inputs. Our findings suggest a path-specific input from DR serotonergic neurons to VTA that promotes reward by the release of glutamate and activation of mesoaccumbens dopamine neurons.
Identifiants
pubmed: 30699344
pii: S2211-1247(19)30022-1
doi: 10.1016/j.celrep.2019.01.014
pmc: PMC6489450
mid: NIHMS1010769
pii:
doi:
Substances chimiques
Amino Acid Transport Systems, Acidic
0
vesicular glutamate transporter 3, mouse
0
Serotonin
333DO1RDJY
Glutamic Acid
3KX376GY7L
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1128-1142.e7Subventions
Organisme : NIGMS NIH HHS
ID : R25 GM060655
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA038453
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH113341
Pays : United States
Organisme : NIDA NIH HHS
ID : F31 DA041303
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107229
Pays : United States
Informations de copyright
Published by Elsevier Inc.
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