Clonal dynamics monitoring during clinical evolution in chronic lymphocytic leukaemia.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 01 2019
30 01 2019
Historique:
received:
25
06
2018
accepted:
03
12
2018
entrez:
1
2
2019
pubmed:
1
2
2019
medline:
11
8
2020
Statut:
epublish
Résumé
Chronic lymphocytic leukaemia is the most prevalent leukaemia in Western countries. It is an incurable disease characterized by a highly variable clinical course. Chronic lymphocytic leukaemia is an ideal model for studying clonal heterogeneity and dynamics during cancer progression, response to therapy and/or relapse because the disease usually develops over several years. Here we report an analysis by deep sequencing of sequential samples taken at different times from the affected organs of two patients with 12- and 7-year disease courses, respectively. One of the patients followed a linear pattern of clonal evolution, acquiring and selecting new mutations in response to salvage therapy and/or allogeneic transplantation, while the other suffered loss of cellular tumoral clones during progression and histological transformation.
Identifiants
pubmed: 30700761
doi: 10.1038/s41598-018-37389-7
pii: 10.1038/s41598-018-37389-7
pmc: PMC6353992
doi:
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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