Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling.
Fatty acid homeostasis
High-fat diet
NASH
PLA2G6
Phospholipid remodeling
Phospholipidomes
Journal
Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
16
08
2018
revised:
22
01
2019
accepted:
25
01
2019
pubmed:
9
2
2019
medline:
4
12
2019
entrez:
9
2
2019
Statut:
ppublish
Résumé
A defect of hepatic remodeling of phospholipids (PL) is seen in non-alcoholic fatty liver disease and steatohepatitis (NASH) indicating pivotal role of PL metabolism in this disease. The deletion of group VIA calcium-independent phospholipase A2 (iPla2β) protects ob/ob mice from hepatic steatosis (BBAlip 1861, 2016, 440-461), however its role in high-fat diet (HFD)-induced NASH is still elusive. Here, wild-type and iPla2β-null mice were subjected to chronic feeding with HFD for 6 months. We showed that protection was observed in iPla2β-null mice with an attenuation of diet-induced body and liver-weight gains, liver enzymes, serum free fatty acids as well as hepatic TG and steatosis scores. iPla2β deficiency under HFD attenuated the levels of 1-stearoyl lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), and lysophosphatidylinositol (LPI) as well as elevation of hepatic arachidonate, arachidonate-containing cholesterol esters and prostaglandin E
Identifiants
pubmed: 30735855
pii: S1388-1981(18)30221-X
doi: 10.1016/j.bbalip.2019.01.012
pii:
doi:
Substances chimiques
Phospholipids
0
Group VI Phospholipases A2
EC 3.1.1.4
Pla2g6 protein, mouse
EC 3.1.1.4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
662-676Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.