DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns.

5-Methylcytosine / analogs & derivatives Animals Cell Line, Tumor CpG Islands DNA Methylation DNA, Neoplasm / metabolism DNA-Binding Proteins / genetics Female Gene Expression Regulation, Neoplastic Histone-Lysine N-Methyltransferase / genetics Histones / genetics Humans Male Methylation Mice, Inbred C57BL Mice, Knockout Myeloid-Lymphoid Leukemia Protein / genetics Neoplasm Proteins / genetics Neoplasms / genetics Promoter Regions, Genetic
5-hydroxymethylation BisChIP-seq CpG islands DNA methylation encroachment H3K4 monomethylation TAB-seq WGBS cancer hypermethylation

Journal

Cancer cell
ISSN: 1878-3686
Titre abrégé: Cancer Cell
Pays: United States
ID NLM: 101130617

Informations de publication

Date de publication:
11 02 2019
Historique:
received: 01 12 2017
revised: 14 11 2018
accepted: 07 01 2019
entrez: 13 2 2019
pubmed: 13 2 2019
medline: 18 12 2019
Statut: ppublish

Résumé

Promoter CpG islands are typically unmethylated in normal cells, but in cancer a proportion are subject to hypermethylation. Using methylome sequencing we identified CpG islands that display partial methylation encroachment across the 5' or 3' CpG island borders. CpG island methylation encroachment is widespread in prostate and breast cancer and commonly associates with gene suppression. We show that the pattern of H3K4me1 at CpG island borders in normal cells predicts the different modes of cancer CpG island hypermethylation. Notably, genetic manipulation of Kmt2d results in concordant alterations in H3K4me1 levels and CpG island border DNA methylation encroachment. Our findings suggest a role for H3K4me1 in the demarcation of CpG island methylation borders in normal cells, which become eroded in cancer.

Identifiants

DOI: 10.1016/j.ccell.2019.01.004 PMID: 30753827
pubmed: 30753827
pii: S1535-6108(19)30038-8
doi: 10.1016/j.ccell.2019.01.004
pii:
doi:

Substances chimiques

DNA, Neoplasm 0
DNA-Binding Proteins 0
Histones 0
KMT2D protein, human 0
Neoplasm Proteins 0
5-hydroxymethylcytosine 1123-95-1
Myeloid-Lymphoid Leukemia Protein 149025-06-9
5-Methylcytosine 6R795CQT4H
Histone-Lysine N-Methyltransferase EC 2.1.1.43
Kmt2b protein, mouse EC 2.1.1.43

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

297-314.e8

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Ksenia Skvortsova (K)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia; Developmental Epigenomics Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.

Etienne Masle-Farquhar (E)

Immunogenomics Laboratory, Immunology Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.

Phuc-Loi Luu (PL)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia.

Jenny Z Song (JZ)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia.

Wenjia Qu (W)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia.

Elena Zotenko (E)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia.

Cathryn M Gould (CM)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia.

Qian Du (Q)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia.

Timothy J Peters (TJ)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia.

Yolanda Colino-Sanguino (Y)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia.

Ruth Pidsley (R)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia.

Shalima S Nair (SS)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia.

Amanda Khoury (A)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia.

Grady C Smith (GC)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia.

Lisa A Miosge (LA)

Immunogenomics Laboratory, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.

Joanne H Reed (JH)

Immunogenomics Laboratory, Immunology Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.

James G Kench (JG)

Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW 2010, Australia; Sydney Medical School, University of Sydney, Sydney, NSW 2010, Australia; Cancer Division, The Kinghorn Cancer Centre, Sydney, NSW 2010, Australia.

Mark A Rubin (MA)

Caryl and Israel Englander Institute for Precision Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York 10021, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York 10065, USA; Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York 10065, USA; Department for Biomedical Research, University of Bern, Bern, CH-3012, Switzerland; Bern Center for Precision Medicine, Inselspital, Bern University Hospital, Bern, CH-3012, Switzerland.

Lisa Horvath (L)

Sydney Medical School, University of Sydney, Sydney, NSW 2010, Australia; St Vincent's Clinical School, UNSW, Sydney, NSW 2010, Australia; Department of Medical Oncology, Chris O'Brien Lifehouse, Sydney, NSW 2050, Australia; Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia; Cancer Division, The Kinghorn Cancer Centre, Sydney, NSW 2010, Australia.

Ozren Bogdanovic (O)

St Vincent's Clinical School, UNSW, Sydney, NSW 2010, Australia; Developmental Epigenomics Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.

Sue Mei Lim (SM)

Department of Anatomy & Developmental Biology, Monash University, Melbourne, VIC 3800, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Melbourne, VIC 3800, Australia; Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC 3800, Australia.

Jose M Polo (JM)

Department of Anatomy & Developmental Biology, Monash University, Melbourne, VIC 3800, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Melbourne, VIC 3800, Australia; Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC 3800, Australia.

Christopher C Goodnow (CC)

Immunogenomics Laboratory, Immunology Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; St Vincent's Clinical School, UNSW, Sydney, NSW 2010, Australia.

Clare Stirzaker (C)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia; St Vincent's Clinical School, UNSW, Sydney, NSW 2010, Australia. Electronic address: c.stirzaker@garvan.org.au.

Susan J Clark (SJ)

Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia; St Vincent's Clinical School, UNSW, Sydney, NSW 2010, Australia. Electronic address: s.clark@garvan.org.au.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Cytosine › 5-Méthyl-cytosine › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Eucaryotes › Animaux › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Ilots CpG › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN tumoral › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Protein Methyltransferases › Histone méthyltransférases › Histone-lysine N-methyltransferase › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Métabolisme › Alkylation › Méthylation › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéine de la leucémie myéloïde-lymphoïde › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Tumeurs › DNA Hypermethylation Encroachment at CpG...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › DNA Hypermethylation Encroachment at CpG...