A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy.

Carbohydrates / chemistry Fluorine / chemistry Lipids / chemistry Magnetic Resonance Spectroscopy / methods

Journal

Journal of visualized experiments : JoVE
ISSN: 1940-087X
Titre abrégé: J Vis Exp
Pays: United States
ID NLM: 101313252

Informations de publication

Date de publication:
30 01 2019
Historique:
entrez: 19 2 2019
pubmed: 19 2 2019
medline: 25 1 2020
Statut: epublish

Résumé

Fluorination has become an effective tool to optimize physicochemical properties of bioactive compounds. One of the applications of fluorine introduction is to modulate the lipophilicity of the compound. In our group, we are interested in the study of the impact of fluorination on lipophilicity of aliphatic fluorohydrins and fluorinated carbohydrates. These are not UV-active, resulting in a challenging lipophilicity determination. Here, we present a straightforward method for the measurement of lipophilicity of fluorinated compounds by

Identifiants

DOI: 10.3791/58567 PMID: 30774129
pubmed: 30774129
doi: 10.3791/58567
doi:

Substances chimiques

Carbohydrates 0
Lipids 0
Fluorine 284SYP0193

Types de publication

Journal Article Research Support, Non-U.S. Gov't Video-Audio Media

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Zhong Wang (Z)

Chemistry, University of Southampton.

Benjamin F Jeffries (BF)

Chemistry, University of Southampton.

Hannah R Felstead (HR)

Chemistry, University of Southampton.

Neil J Wells (NJ)

Chemistry, University of Southampton.

Elisabetta Chiarparin (E)

Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca.

Bruno Linclau (B)

Chemistry, University of Southampton; bruno.linclau@soton.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Glucides › A New Straightforward Method for Lipophilicity...
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Halogènes › Fluor › A New Straightforward Method for Lipophilicity...
questionsmedicales.fr › Lipides › A New Straightforward Method for Lipophilicity...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › A New Straightforward Method for Lipophilicity...