Zinc deficiency in patients with chronic pancreatitis.
Adolescent
Adult
Aged
Child
Child, Preschool
Exocrine Pancreatic Insufficiency
/ blood
Feces
/ enzymology
Female
Humans
Infant
Infant, Newborn
Male
Malnutrition
/ blood
Middle Aged
Pancreas
/ metabolism
Pancreatic Elastase
/ analysis
Pancreatitis, Chronic
/ blood
Prevalence
Retrospective Studies
Risk Factors
Smoking
/ epidemiology
Sweden
/ epidemiology
Young Adult
Zinc
/ blood
Chronic pancreatitis
Malnutrition
Pancreas
Pancreatic exocrine insufficiency
Zinc
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
07 Feb 2019
07 Feb 2019
Historique:
received:
06
12
2018
revised:
10
01
2019
accepted:
14
01
2019
entrez:
19
2
2019
pubmed:
19
2
2019
medline:
6
4
2019
Statut:
ppublish
Résumé
Zinc is a key element in numerous proteins and plays an important role in essential cell functions such as defense against free radicals and DNA damage repair. Chronic pancreatitis (CP) is a chronic inflammation with progressive fibrosis of pancreas ultimately resulting in pancreatic exocrine insufficiency (PEI), which is associated with malnutrition. Studies analyzing zinc levels in patients with CP are sparse and lead to conflicting results. To investigate serum zinc levels in patients with CP of various etiologies. Between October 2015 and March 2018, patients with a diagnosis of CP were identified and recruited from the Pancreatic Outpatient Clinic at the Karolinska University Hospital in Stockholm, Sweden. Demographic, clinical and laboratory data were analyzed. Etiology of CP was determined according to the M-ANNHEIM classification system into the following etiological subcategories: alcohol consumption, nicotine consumption, hereditary factors, efferent pancreatic duct factors and immunological factors. Pancreatic exocrine function was defined as normal (fecal elastase 1 > 200 μg/g), mildly reduced (100-200 μg/g) and severely reduced (fecal elastase 1 < 100 μg/g). A total of 150 patients were included in the analysis. Zinc deficiency (< 11 μmol/L) was present in 39 (26.0%) of patients: 22 females and 17 males. In the group of patients with zinc deficiency, 76.7% of patients had an exocrine pancreatic insufficiency (FE-1 < 200 μg/g). Older age was significantly associated with low zinc levels. Following a univariate analysis, patients aged 60-69 and patients ≥ 70 years of age had a significantly higher prevalence of zinc deficiencies compared to patients < 40 years of age [OR: 3.8, 95%CI (1.08-13.4); Zinc deficiency is common in patients with CP and is significantly associated with age ≥ 60, smoking and the number of pack-years, but not with PEI.
Sections du résumé
BACKGROUND
BACKGROUND
Zinc is a key element in numerous proteins and plays an important role in essential cell functions such as defense against free radicals and DNA damage repair. Chronic pancreatitis (CP) is a chronic inflammation with progressive fibrosis of pancreas ultimately resulting in pancreatic exocrine insufficiency (PEI), which is associated with malnutrition. Studies analyzing zinc levels in patients with CP are sparse and lead to conflicting results.
AIM
OBJECTIVE
To investigate serum zinc levels in patients with CP of various etiologies.
METHODS
METHODS
Between October 2015 and March 2018, patients with a diagnosis of CP were identified and recruited from the Pancreatic Outpatient Clinic at the Karolinska University Hospital in Stockholm, Sweden. Demographic, clinical and laboratory data were analyzed. Etiology of CP was determined according to the M-ANNHEIM classification system into the following etiological subcategories: alcohol consumption, nicotine consumption, hereditary factors, efferent pancreatic duct factors and immunological factors. Pancreatic exocrine function was defined as normal (fecal elastase 1 > 200 μg/g), mildly reduced (100-200 μg/g) and severely reduced (fecal elastase 1 < 100 μg/g).
RESULTS
RESULTS
A total of 150 patients were included in the analysis. Zinc deficiency (< 11 μmol/L) was present in 39 (26.0%) of patients: 22 females and 17 males. In the group of patients with zinc deficiency, 76.7% of patients had an exocrine pancreatic insufficiency (FE-1 < 200 μg/g). Older age was significantly associated with low zinc levels. Following a univariate analysis, patients aged 60-69 and patients ≥ 70 years of age had a significantly higher prevalence of zinc deficiencies compared to patients < 40 years of age [OR: 3.8, 95%CI (1.08-13.4);
CONCLUSION
CONCLUSIONS
Zinc deficiency is common in patients with CP and is significantly associated with age ≥ 60, smoking and the number of pack-years, but not with PEI.
Identifiants
pubmed: 30774274
doi: 10.3748/wjg.v25.i5.600
pmc: PMC6371007
doi:
Substances chimiques
Pancreatic Elastase
EC 3.4.21.36
Zinc
J41CSQ7QDS
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
600-607Déclaration de conflit d'intérêts
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
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