An ancillary genomics system to support the return of pharmacogenomic results.
electronic health record
genetic testing
pharmacogenomics
Journal
Journal of the American Medical Informatics Association : JAMIA
ISSN: 1527-974X
Titre abrégé: J Am Med Inform Assoc
Pays: England
ID NLM: 9430800
Informations de publication
Date de publication:
01 04 2019
01 04 2019
Historique:
received:
13
06
2017
revised:
15
10
2018
accepted:
20
12
2018
pubmed:
20
2
2019
medline:
27
2
2020
entrez:
20
2
2019
Statut:
ppublish
Résumé
Existing approaches to managing genetic and genomic test results from external laboratories typically include filing of text reports within the electronic health record, making them unavailable in many cases for clinical decision support. Even when structured computable results are available, the lack of adopted standards requires considerations for processing the results into actionable knowledge, in addition to storage and management of the data. Here, we describe the design and implementation of an ancillary genomics system used to receive and process heterogeneous results from external laboratories, which returns a descriptive phenotype to the electronic health record in support of pharmacogenetic clinical decision support.
Identifiants
pubmed: 30778576
pii: 5342160
doi: 10.1093/jamia/ocy187
pmc: PMC6402311
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
306-310Subventions
Organisme : NLM NIH HHS
ID : F31 LM012492
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006388
Pays : United States
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Références
Genet Med. 2012 Apr 05;14(8):713-719
pubmed: 22481129
J Biomed Inform. 2012 Jun;45(3):419-22
pubmed: 22223081
J Biomed Inform. 2012 Oct;45(5):950-7
pubmed: 22521718
JMIR Med Inform. 2014 Aug 11;2(2):e17
pubmed: 25599817
J Am Med Inform Assoc. 2014 Feb;21(e1):e117-21
pubmed: 24013137
Clin Pharmacol Ther. 2013 Aug;94(2):214-7
pubmed: 23588317
Clin Pharmacol Ther. 2016 Feb;99(2):157-60
pubmed: 26418054
Hum Mutat. 2011 May;32(5):532-6
pubmed: 21432942
Am J Med Genet C Semin Med Genet. 2014 Mar;166C(1):45-55
pubmed: 24619595
J Biomed Inform. 2007 Feb;40(1):44-6
pubmed: 16616698
Genet Med. 2015 Nov;17(11):939-42
pubmed: 25741865
JAMA. 2013 Mar 27;309(12):1237-8
pubmed: 23494000
Clin Pharmacol Ther. 2014 Oct;96(4):482-9
pubmed: 24960519
Genet Med. 2013 Oct;15(10):761-71
pubmed: 23743551
Mayo Clin Proc. 2014 Jan;89(1):25-33
pubmed: 24388019
J Am Med Inform Assoc. 2017 May 1;24(3):513-519
pubmed: 27789569
Appl Clin Inform. 2016 Jun 01;7(2):461-76
pubmed: 27437054
J Am Med Inform Assoc. 2014 Feb;21(e1):e143-6
pubmed: 24001515
Genet Med. 2013 Oct;15(10):772-8
pubmed: 24071798
Clin Pharmacol Ther. 2012 Nov;92(5):563-6
pubmed: 22990750
Am J Hum Genet. 2016 Jun 2;98(6):1051-1066
pubmed: 27181682
Clin Pharmacol Ther. 2017 Aug;102(2):254-264
pubmed: 28390138
Clin Pharmacol Ther. 2011 Mar;89(3):464-7
pubmed: 21270786
BMC Med Genomics. 2016 Jan 05;9:1
pubmed: 26729011
Am J Med Genet C Semin Med Genet. 2014 Mar;166C(1):56-67
pubmed: 24616371
Stud Health Technol Inform. 2013;192:338-42
pubmed: 23920572