Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.
Aldehyde-Lyases
/ genetics
Animals
Carcinogenesis
/ genetics
Cells, Cultured
Colitis
/ etiology
Colon
/ metabolism
Colonic Neoplasms
/ complications
Female
Inflammation
/ etiology
Lysophospholipids
/ physiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Signal Transduction
/ physiology
Sphingosine
/ analogs & derivatives
Tumor Microenvironment
/ physiology
Journal
Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
01
06
2018
accepted:
05
01
2019
revised:
03
01
2019
pubmed:
1
3
2019
medline:
18
12
2019
entrez:
1
3
2019
Statut:
ppublish
Résumé
A role of sphingolipids for inflammatory bowel disease and cancer is evident. However, the relative and separate contribution of sphingolipid deterioration in inflammation versus carcinogenesis for the pathophysiology of colitis-associated colon cancer (CAC) was unknown and therefore examined in this study. We performed isogenic bone marrow transplantation of inducible sphingosine-1-phosphate (S1P) lyase knockout mice to specifically modulate sphingolipids and associated genes and proteins in a compartment-specific way in a DSS/AOM mediated CAC model. 3D organoid cultures were used in vitro. S1P lyase (SGPL1) knockout in either immune cells or tissue, caused local sphingolipid accumulation leading to a dichotomic development of CAC: Immune cell SGPL1 knockout (I-SGPL
Identifiants
pubmed: 30816345
doi: 10.1038/s41388-019-0758-x
pii: 10.1038/s41388-019-0758-x
doi:
Substances chimiques
Lysophospholipids
0
sphingosine 1-phosphate
26993-30-6
Aldehyde-Lyases
EC 4.1.2.-
sphingosine 1-phosphate lyase (aldolase)
EC 4.1.2.27
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4788-4803Références
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