Mechanistic understanding of abnormal reverse phase chromatographic behavior of basic analytes in the presence of sodium dodecyl sulfate.

Buffers Chromatography, Reverse-Phase Hydrogen-Ion Concentration Sodium Dodecyl Sulfate / chemistry Surface-Active Agents / chemistry
Basic analytes Peak splitting Retention time shifting Reverse phase chromatography Sodium dodecyl sulfate (SDS) Surfactant

Journal

Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488

Informations de publication

Date de publication:
21 Jun 2019
Historique:
received: 06 11 2018
revised: 17 02 2019
accepted: 20 02 2019
pubmed: 4 3 2019
medline: 6 7 2019
entrez: 4 3 2019
Statut: ppublish

Résumé

In the process of dissolution method development for Merck proprietary compound A, a basic analyte, abnormal chromatographic behavior involving peak splitting and retention time shifting in the presence of sodium dodecyl sulfate (SDS) in the sample solution was observed. A mechanistic study was conducted and the level and type of surfactant, along with the pK

Identifiants

DOI: 10.1016/j.chroma.2019.02.044 PMID: 30826076
pubmed: 30826076
pii: S0021-9673(19)30192-X
doi: 10.1016/j.chroma.2019.02.044
pii:
doi:

Substances chimiques

Buffers 0
Surface-Active Agents 0
Sodium Dodecyl Sulfate 368GB5141J

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

108-116

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Adam Socia (A)

Analytical Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, USA. Electronic address: Adam_Socia@merck.com.

Yong Liu (Y)

Analytical Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, USA.

Andreas Abend (A)

Analytical Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, USA.

W Peter Wuelfing (WP)

Analytical Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, USA.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Substances tampon › Mechanistic understanding of abnormal reverse...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase inverse › Mechanistic understanding of abnormal reverse...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Mechanistic understanding of abnormal reverse...
questionsmedicales.fr › Lipides › Alcools gras › Dodécan-1-ol › Dodécyl-sulfate de sodium › Mechanistic understanding of abnormal reverse...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Tensioactifs › Mechanistic understanding of abnormal reverse...