Safety of Intradermal/Subcutaneous Lidocaine With Epinephrine Use in Dermatologic Surgery.


Journal

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
ISSN: 1524-4725
Titre abrégé: Dermatol Surg
Pays: United States
ID NLM: 9504371

Informations de publication

Date de publication:
01 2020
Historique:
pubmed: 5 3 2019
medline: 4 4 2020
entrez: 5 3 2019
Statut: ppublish

Résumé

Recently, the safety of lidocaine plus epinephrine use in outpatient surgery has come under scrutiny despite its long history of use in outpatient dermatologic procedures and surgeries. To assess the frequency of crash cart and other emergency interventions during Mohs micrographic surgery when lidocaine plus epinephrine is used as a local anesthetic and evaluate patient comorbidities associated with these events. A retrospective chart review was conducted in an outpatient Mohs micrographic surgery clinic. One thousand one hundred twenty-seven Mohs cases were reviewed from the period of March 2015 to June 2016 with 864 meeting the inclusion criteria of patient weight, medical history, and amount of lidocaine administered recorded. No adverse events requiring emergency intervention with a crash cart or transfer to the emergency department occurred despite a patient population with advanced age and a wide range of comorbidities. No serious adverse events requiring emergency intervention were associated with lidocaine with epinephrine doses administered below the Food and Drug Administration recommended maximum. The authors did not find evidence from this study or after a literature search to support the requirement for a crash cart and other emergency equipment to be present during procedures.

Sections du résumé

BACKGROUND
Recently, the safety of lidocaine plus epinephrine use in outpatient surgery has come under scrutiny despite its long history of use in outpatient dermatologic procedures and surgeries.
OBJECTIVE
To assess the frequency of crash cart and other emergency interventions during Mohs micrographic surgery when lidocaine plus epinephrine is used as a local anesthetic and evaluate patient comorbidities associated with these events.
MATERIALS AND METHODS
A retrospective chart review was conducted in an outpatient Mohs micrographic surgery clinic.
RESULTS
One thousand one hundred twenty-seven Mohs cases were reviewed from the period of March 2015 to June 2016 with 864 meeting the inclusion criteria of patient weight, medical history, and amount of lidocaine administered recorded. No adverse events requiring emergency intervention with a crash cart or transfer to the emergency department occurred despite a patient population with advanced age and a wide range of comorbidities.
CONCLUSION
No serious adverse events requiring emergency intervention were associated with lidocaine with epinephrine doses administered below the Food and Drug Administration recommended maximum. The authors did not find evidence from this study or after a literature search to support the requirement for a crash cart and other emergency equipment to be present during procedures.

Identifiants

pubmed: 30829774
doi: 10.1097/DSS.0000000000001900
pii: 00042728-202001000-00005
doi:

Substances chimiques

Anesthetics, Local 0
Sympathomimetics 0
Lidocaine 98PI200987
Epinephrine YKH834O4BH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

26-30

Références

Lidocaine Hydrochloride and Epinephrine Injection, USP (For Infiltration and Nerve Block) [package insert]. Lake Forest, IL:Hospira Inc.; 2008.
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Cummins TR. Setting up for the block: the mechanism underlying lidocaine's use-dependent inhibition of sodium channels. J Physiol (Lond) 2007;582:11.
Berde CB. Toxicity of local anesthetics in infants and children. J Pediatr 1993;122:S14–20.
Wolfe JW, Butterworth JF. Local anesthetic systemic toxicity: update on mechanisms and treatment. Curr Opin Anaesthesiol 2011;24:561–6.
Texas State Legislature. Senate Bill (SB) 978. 2013–2014. Available from: https://capitol.texas.gov/tlodocs/83R/billtext/html/SB00978F.htm. Accessed February 24, 2019.
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Stoelting RK. Plasma lidocaine concentrations following subcutaneous or submucosal epinephrine-lidocaine injection. Anesth Analg 1978;57:724–6.
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Alam M, Schaeffer MR, Geisler A, Poon E, et al. Safety of local intracutaneous lidocaine anesthesia used by dermatologic surgeons for skin cancer excision and postcancer reconstruction: quantification of standard injection volumes and adverse event rates. Derm Surg 2016;42:1320–4.
Kimyai-Asadi A, Goldberg LH, Petersone SR, Silapint S, et al. The incidence of major complications from mohs micrographic surgery performed in office-based and hospital-based settings. J Am Acad Derm 2005;53:628–34.
Hancox JG, Venkat AP, Coldiron B, Feldman SR, et al. The safety of office-based surgery: review of recent literature from several disciplines. Arch Dermatol 2004;140:1379–82.
Manternach T, Housman TS, Williford PW, Teuschler H, et al. Surgical treatment of nonmelanoma skin cancer in the medicare population. Dermatol Surg 2003;29:1167–9.
Chen JG, Fleischer AB Jr, Smith ED, Kancler C, et al. Cost of nonmelanoma skin cancer treatment in the United States. Dermatol Surg 2001;27:1035–8.

Auteurs

Jason M Hirshburg (JM)

Dell Medical School, University of Texas at Austin, Austin, Texas.

Dayna G Diven (DG)

Dell Medical School, University of Texas at Austin, Austin, Texas.

Chloe Edmiston (C)

Cutaneous Surgery Center of Austin, Austin, Texas.

Susan E Dozier (SE)

Cutaneous Surgery Center of Austin, Austin, Texas.

Meghan Woody (M)

Dell Medical School, University of Texas at Austin, Austin, Texas.

Matthew C Fox (MC)

Dell Medical School, University of Texas at Austin, Austin, Texas.
Austin Dermatologic Surgery Center, University of Texas at Austin, Austin, Texas.

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Classifications MeSH