Whole Exome Sequencing Guides Pharmacotherapy for an Adolescent With Autism Spectrum Disorder and Psychosis.

Adolescent Autism Spectrum Disorder / drug therapy DNA-Binding Proteins / genetics Disease Management Exome Genetic Predisposition to Disease Humans Male Psychotic Disorders / drug therapy Transcription Factors / genetics Exome Sequencing

Journal

Journal of the American Academy of Child and Adolescent Psychiatry
ISSN: 1527-5418
Titre abrégé: J Am Acad Child Adolesc Psychiatry
Pays: United States
ID NLM: 8704565

Informations de publication

Date de publication:
03 2019
Historique:
received: 08 06 2018
revised: 24 09 2018
accepted: 19 10 2018
entrez: 6 3 2019
pubmed: 6 3 2019
medline: 3 6 2020
Statut: ppublish

Résumé

Genomic testing, including whole exome sequencing (WES), can result in specific changes to medical management. To illustrate the clinical utility of WES for complex neuropsychiatric disease, we report a male adolescent with autism spectrum disorder, psychosis, and regression and discuss how the WES findings guided his pharmacologic management.

Identifiants

DOI: 10.1016/j.jaac.2018.09.432 PMID: 30832905
pubmed: 30832905
pii: S0890-8567(18)31895-1
doi: 10.1016/j.jaac.2018.09.432
pii:
doi:

Substances chimiques

DNA-Binding Proteins 0
Transcription Factors 0
HIVEP2 protein, human 148770-78-9

Types de publication

Case Reports Letter

Langues

eng

Sous-ensembles de citation

IM

Pagination

376-377

Informations de copyright

Copyright © 2018 American Academy of Child and Adolescent Psychiatry. All rights reserved.

Auteurs

Kristen Wigby (K)

University of California, San Diego, CA. Electronic address: kwithers@ucsd.edu.

Samuel Nicolas (S)

Naval Medical Center, San Diego, CA.

Matthew Carpinello (M)

Naval Medical Center, San Diego, CA.

Michael T Ricciardi (MT)

Naval Medical Center, San Diego, CA.

Mary J Willis (MJ)

Naval Medical Center, San Diego, CA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Whole Exome Sequencing Guides Pharmacotherapy...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Whole Exome Sequencing Guides Pharmacotherapy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Whole Exome Sequencing Guides Pharmacotherapy...
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Prise en charge de la maladie › Whole Exome Sequencing Guides Pharmacotherapy...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Exome › Whole Exome Sequencing Guides Pharmacotherapy...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Whole Exome Sequencing Guides Pharmacotherapy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Whole Exome Sequencing Guides Pharmacotherapy...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Troubles psychotiques › Whole Exome Sequencing Guides Pharmacotherapy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Whole Exome Sequencing Guides Pharmacotherapy...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Séquençage de l'exome › Whole Exome Sequencing Guides Pharmacotherapy...