The prognostic significance of positive peritoneal cytology in endometrial cancer and its correlations with L1-CAM biomarker.
Adenocarcinoma, Clear Cell
/ metabolism
Aged
Biomarkers, Tumor
/ metabolism
Carcinoma, Squamous Cell
/ metabolism
Case-Control Studies
Cystadenocarcinoma, Serous
/ metabolism
Cytodiagnosis
Endometrial Neoplasms
/ metabolism
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
/ metabolism
Neoplasm Staging
Neural Cell Adhesion Molecule L1
/ metabolism
Peritoneal Neoplasms
/ metabolism
Retrospective Studies
Risk Factors
Survival Rate
Endometrial cancer
L1CAM
Peritoneal cytology
Journal
Surgical oncology
ISSN: 1879-3320
Titre abrégé: Surg Oncol
Pays: Netherlands
ID NLM: 9208188
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
07
08
2018
revised:
28
11
2018
accepted:
02
01
2019
entrez:
11
3
2019
pubmed:
11
3
2019
medline:
10
7
2019
Statut:
ppublish
Résumé
The aim of this study was to evaluate the prognostic role of positive peritoneal cytology (PPC) in a cohort of patients with endometrial cancer (EC). The secondary objective was to correlate the PPC and the expression of L1CAM in a group of patients with recurrence endometrial disease. All women diagnosed with EC and who performed a peritoneal cytology at "Regina Elena" National Cancer Institute of Rome from 2001 to 2013 were included in the study. Patients were divided into two groups according to positivity at peritoneal cytology. Moreover, patients with a recurrence disease and whose a tissue microarray (TMA) tumor sample was available underwent a L1CAM analysis. Seven hundred sixty six patients underwent to EC staging in our Institute: 696 (90.8%) with negative and 70 (9.2%) with positive cytology. Five-year recurrence rate was higher in women with PPC (46.9% vs 18.4%, p = 0 < 0.0001) and, in particular, distant recurrence (86.7% vs 53.4%, p = 0.03). Moreover, we found an interesting pattern of recurrence disease in the group of early stage of EC with NPC and positive L1CAM. Our results support the data that PPC may be a potential prognostic factor in early EC, due to its significant association with other risk factors and its significant influence on survival. Our findings confirm the need for large studies that point out the role of PPC and new prognostic factors, including biomarkers as L1CAM.
Sections du résumé
BACKGROUND
BACKGROUND
The aim of this study was to evaluate the prognostic role of positive peritoneal cytology (PPC) in a cohort of patients with endometrial cancer (EC). The secondary objective was to correlate the PPC and the expression of L1CAM in a group of patients with recurrence endometrial disease.
METHODS
METHODS
All women diagnosed with EC and who performed a peritoneal cytology at "Regina Elena" National Cancer Institute of Rome from 2001 to 2013 were included in the study. Patients were divided into two groups according to positivity at peritoneal cytology. Moreover, patients with a recurrence disease and whose a tissue microarray (TMA) tumor sample was available underwent a L1CAM analysis.
RESULTS
RESULTS
Seven hundred sixty six patients underwent to EC staging in our Institute: 696 (90.8%) with negative and 70 (9.2%) with positive cytology. Five-year recurrence rate was higher in women with PPC (46.9% vs 18.4%, p = 0 < 0.0001) and, in particular, distant recurrence (86.7% vs 53.4%, p = 0.03). Moreover, we found an interesting pattern of recurrence disease in the group of early stage of EC with NPC and positive L1CAM.
CONCLUSIONS
CONCLUSIONS
Our results support the data that PPC may be a potential prognostic factor in early EC, due to its significant association with other risk factors and its significant influence on survival. Our findings confirm the need for large studies that point out the role of PPC and new prognostic factors, including biomarkers as L1CAM.
Identifiants
pubmed: 30851892
pii: S0960-7404(18)30306-2
doi: 10.1016/j.suronc.2019.01.001
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Neural Cell Adhesion Molecule L1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
151-157Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.