Exploring Endocytosis and Intracellular Trafficking of the Human Serotonin
Aminopyridines
/ pharmacology
Animals
Antibodies, Monoclonal
/ immunology
Cell Membrane
/ metabolism
Drug Inverse Agonism
Endocytosis
/ drug effects
Fluorescent Dyes
/ chemistry
Goats
HEK293 Cells
Humans
Piperazines
/ pharmacology
Protein Transport
/ physiology
Pyridines
/ pharmacology
Rabbits
Receptor, Serotonin, 5-HT1A
/ immunology
Serotonin Antagonists
/ pharmacology
Journal
Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623
Informations de publication
Date de publication:
04 06 2019
04 06 2019
Historique:
pubmed:
22
3
2019
medline:
3
6
2020
entrez:
22
3
2019
Statut:
ppublish
Résumé
G protein-coupled receptors (GPCRs) represent the largest class of receptors involved in signal transduction across cell membranes and are major drug targets in all clinical areas. Endocytosis of GPCRs offers a regulatory mechanism for sustaining their signaling within a stringent spatiotemporal regime. In this work, we explored agonist-induced endocytosis of the human serotonin
Identifiants
pubmed: 30896156
doi: 10.1021/acs.biochem.9b00033
doi:
Substances chimiques
Aminopyridines
0
Antibodies, Monoclonal
0
Fluorescent Dyes
0
Piperazines
0
Pyridines
0
Serotonin Antagonists
0
Receptor, Serotonin, 5-HT1A
112692-38-3
4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine
155204-23-2
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
71IH826FEG
4-(2' methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-fluorobenzamido)ethyl)piperazine
81KHI46E5L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM