Safety and Effectiveness of Longer-Term Phentermine Use: Clinical Outcomes from an Electronic Health Record Cohort.
Adolescent
Adult
Anti-Obesity Agents
/ therapeutic use
Cardiovascular Diseases
/ chemically induced
Cause of Death
Cohort Studies
Electronic Health Records
/ statistics & numerical data
Female
Humans
Male
Middle Aged
Mortality
Obesity
/ drug therapy
Phentermine
/ therapeutic use
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome
United States
/ epidemiology
Weight Loss
/ drug effects
Young Adult
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
09
11
2018
accepted:
09
01
2019
entrez:
23
3
2019
pubmed:
23
3
2019
medline:
28
2
2020
Statut:
ppublish
Résumé
The aim of this work was to study weight loss and risk of cardiovascular disease (CVD) or death associated with longer-term phentermine use. Using electronic health record data, 13,972 adults were identified with a first phentermine fill in 2010 to 2015, creating exposure categories according to a patient's duration of use (referent: ≤ 3 months). Multivariable linear models were used to compare percent weight loss across categories at 6, 12, and 24 months, and Cox proportional hazards models were used to compare risk of composite CVD or death, up to 3 years after starting phentermine. The cohort was 84% female and 45% white, with a mean (SD) baseline age 43.5 (10.7) years and BMI of 37.8 (7.2) kg/m Greater weight loss without increased risk of incident CVD or death was observed in patients using phentermine monotherapy for longer than 3 months. Despite the limitations of the observational design, this study supports the effectiveness and safety of longer-term phentermine use for low-risk individuals.
Substances chimiques
Anti-Obesity Agents
0
Phentermine
C045TQL4WP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
591-602Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2019 The Obesity Society.