Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma.
Amino Acid Sequence
Crystallography, X-Ray
Cyclic AMP
/ metabolism
Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
/ chemistry
Dipyridamole
/ pharmacology
Drug Evaluation, Preclinical
Enzyme Activators
/ chemistry
Holoenzymes
/ metabolism
Leishmania
/ drug effects
Molecular Docking Simulation
Nucleosides
/ analogs & derivatives
Phosphorylation
/ drug effects
Signal Transduction
Trypanosoma brucei brucei
/ drug effects
Tubercidin
/ pharmacology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
29 03 2019
29 03 2019
Historique:
received:
07
07
2018
accepted:
07
03
2019
entrez:
31
3
2019
pubmed:
31
3
2019
medline:
6
5
2019
Statut:
epublish
Résumé
Protein kinase A (PKA), the main effector of cAMP in eukaryotes, is a paradigm for the mechanisms of ligand-dependent and allosteric regulation in signalling. Here we report the orthologous but cAMP-independent PKA of the protozoan Trypanosoma and identify 7-deaza-nucleosides as potent activators (EC
Identifiants
pubmed: 30926779
doi: 10.1038/s41467-019-09338-z
pii: 10.1038/s41467-019-09338-z
pmc: PMC6440977
doi:
Substances chimiques
Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
0
Enzyme Activators
0
Holoenzymes
0
Nucleosides
0
Dipyridamole
64ALC7F90C
Cyclic AMP
E0399OZS9N
Tubercidin
M351LCX45Y
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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