Cognitive slowing and its underlying neurobiology in temporal lobe epilepsy.
Adult
Brain
/ diagnostic imaging
Cognition
/ physiology
Cognition Disorders
/ diagnostic imaging
Connectome
Epilepsy, Temporal Lobe
/ complications
Executive Function
/ physiology
Female
Humans
Language
Magnetic Resonance Imaging
Male
Memory
/ physiology
Middle Aged
Neuropsychological Tests
Young Adult
Cognition
Epilepsy
MRI
Processing speed
TLE
Journal
Cortex; a journal devoted to the study of the nervous system and behavior
ISSN: 1973-8102
Titre abrégé: Cortex
Pays: Italy
ID NLM: 0100725
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
26
07
2018
revised:
06
12
2018
accepted:
23
02
2019
pubmed:
31
3
2019
medline:
2
10
2020
entrez:
31
3
2019
Statut:
ppublish
Résumé
Cognitive slowing is a known but comparatively under-investigated neuropsychological complication of the epilepsies in relation to other known cognitive comorbidities such as memory, executive function and language. Here we focus on a novel metric of processing speed, characterize its relative salience compared to other cognitive difficulties in epilepsy, and explore its underlying neurobiological correlates. Research participants included 55 patients with temporal lobe epilepsy (TLE) and 58 healthy controls from the Epilepsy Connectome Project (ECP) who were administered a battery of tests yielding 14 neuropsychological measures, including selected tests from the NIH Toolbox-Cognitive Battery, and underwent 3T MRI and resting state fMRI. TLE patients exhibited a pattern of generalized cognitive impairment with very few lateralized abnormalities. Using the neuropsychological measures, machine learning (Support Vector Machine binary classification model) classified the TLE and control groups with 74% accuracy with processing speed (NIH Toolbox Pattern Comparison Processing Speed Test) the best predictor. In TLE, slower processing speed was associated predominantly with decreased local gyrification in regions including the rostral and caudal middle frontal gyrus, inferior precentral cortex, insula, inferior parietal cortex (angular and supramarginal gyri), lateral occipital cortex, rostral anterior cingulate, and medial orbital frontal regions, as well as three small regions of the temporal lobe. Slower processing speed was also associated with decreased connectivity between the primary visual cortices in both hemispheres and the left supplementary motor area, as well as between the right parieto-occipital sulcus and right middle insular area. Overall, slowed processing speed is an important cognitive comorbidity of TLE associated with altered brain structure and connectivity.
Identifiants
pubmed: 30927560
pii: S0010-9452(19)30090-5
doi: 10.1016/j.cortex.2019.02.022
pmc: PMC6650302
mid: NIHMS1525645
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-52Subventions
Organisme : NINDS NIH HHS
ID : U01 NS093650
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090256
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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