Novel insights into pasteurellosis in captive pinnipeds.
Bioinformatics
Pasteurella multocida pinnipeds
Pneumonia
Septicemia
Whole genome sequencing
Journal
Veterinary microbiology
ISSN: 1873-2542
Titre abrégé: Vet Microbiol
Pays: Netherlands
ID NLM: 7705469
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
15
01
2019
revised:
12
03
2019
accepted:
12
03
2019
entrez:
9
4
2019
pubmed:
9
4
2019
medline:
3
5
2019
Statut:
ppublish
Résumé
Pasteurella multocida is a heterogeneous bacterium, which has the capacity to cause disease in a wide range of host species and is also recognized as an important zoonotic pathogen. Two sequential deaths in captive fur seals occurred at Sea World, Australia during December 2017. A fibrinosuppurative bronchopneumonia in a Subantarctic fur seal (Arctocephalus tropicalis) resulted in death within 24 h of nonspecific signs of illness, whereas a septic peritonitis in a New Zealand fur seal (Arctocephalus forsteri) resulted in death within 12 h of clinical presentation. The cases happened within three days in two different pool locations, although both had previously been housed in the same area. A total of six Pasteurella multocida isolates were obtained from several internal organs at necropsy in both cases and were subjected to whole genome sequencing and phylogenomic analysis. In-silico typing of the isolates revealed that all belonged to Multi-Locus Sequence Type 7 and carried lipopolysaccharide outer core biosynthesis loci Type 3. Phylogenomic analysis of the isolates confirmed that the isolates were near identical at the core genome level, suggesting acquisition from a common source. The results also revealed the presence of within host and across animal diversity of P. multocida isolates for the first time even in a clearly connected outbreak.
Identifiants
pubmed: 30955815
pii: S0378-1135(19)30048-3
doi: 10.1016/j.vetmic.2019.03.017
pmc: PMC7117180
pii:
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
232-237Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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