Extracellular RNA in viral-host interactions: Thinking outside the cell.
RNA interference
extracellular RNA
extracellular vesicle
host-pathogen
microRNA
Journal
Wiley interdisciplinary reviews. RNA
ISSN: 1757-7012
Titre abrégé: Wiley Interdiscip Rev RNA
Pays: United States
ID NLM: 101536955
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
05
01
2019
revised:
13
03
2019
accepted:
14
03
2019
pubmed:
10
4
2019
medline:
18
12
2019
entrez:
10
4
2019
Statut:
ppublish
Résumé
Small RNAs and their associated RNA interference (RNAi) pathways underpin diverse mechanisms of gene regulation and genome defense across all three kingdoms of life and are integral to virus-host interactions. In plants, fungi and many animals, an ancestral RNAi pathway exists as a host defense mechanism whereby viral double-stranded RNA is processed to small RNAs that enable recognition and degradation of the virus. While this antiviral RNAi pathway is not generally thought to be present in mammals, other RNAi mechanisms can influence infection through both viral- and host-derived small RNAs. Furthermore, a burgeoning body of data suggests that small RNAs in mammals can function in a non-cell autonomous manner to play various roles in cell-to-cell communication and disease through their transport in extracellular vesicles. While vesicular small RNAs have not been proposed as an antiviral defense pathway per se, there is increasing evidence that the export of host- or viral-derived RNAs from infected cells can influence various aspects of the infection process. This review discusses the current knowledge of extracellular RNA functions in viral infection and the technical challenges surrounding this field of research. This article is categorized under: Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA in Disease and Development > RNA in Disease Regulatory RNAs/RNAi/Riboswitches > RNAi: Mechanisms of Action.
Identifiants
pubmed: 30963709
doi: 10.1002/wrna.1535
pmc: PMC6617787
doi:
Substances chimiques
RNA, Small Untranslated
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1535Subventions
Organisme : Wellcome Trust
ID : 097394/Z/11/Z
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. WIREs RNA published by Wiley Periodicals, Inc.
Références
Cell Microbiol. 2013 Mar;15(3):412-29
pubmed: 23072732
RNA. 2018 Mar;24(3):423-435
pubmed: 29282313
J Dent Res. 2018 Oct;97(11):1236-1243
pubmed: 29702004
Sci Rep. 2017 Feb 01;7:41052
pubmed: 28145468
EMBO J. 2013 Apr 17;32(8):1115-27
pubmed: 23511973
Cell Rep. 2016 Oct 11;17(3):799-808
pubmed: 27732855
J Biol Chem. 2017 Sep 8;292(36):14764
pubmed: 28887434
Blood. 2012 Jan 19;119(3):756-66
pubmed: 22031862
Nat Cell Biol. 2008 Dec;10(12):1470-6
pubmed: 19011622
Nucleic Acids Res. 2009 Oct;37(19):6575-86
pubmed: 19729508
J Virol. 2013 Sep;87(18):10334-47
pubmed: 23864627
RNA Biol. 2015;12(6):579-85
pubmed: 25849078
J Neurochem. 2019 May;149(4):518-534
pubmed: 30556910
PLoS Biol. 2014 Jun 03;12(6):e1001874
pubmed: 24893313
Front Immunol. 2019 Jan 15;9:3164
pubmed: 30697216
Nucleic Acids Res. 2012 Oct;40(18):9272-85
pubmed: 22821563
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10592-7
pubmed: 12947040
Front Genet. 2013 Jun 24;4:120
pubmed: 23805153
Annu Rev Virol. 2016 Sep 29;3(1):309-332
pubmed: 27578438
Nat Microbiol. 2017 Apr 25;2:17052
pubmed: 28440277
Genes (Basel). 2018 May 10;9(5):
pubmed: 29748504
J Extracell Vesicles. 2014 Aug 04;3:
pubmed: 25143819
Mol Ther. 2015 Oct;23(10):1622-9
pubmed: 26156244
Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10584-10589
pubmed: 28923936
Wiley Interdiscip Rev RNA. 2019 Jul;10(4):e1535
pubmed: 30963709
J Genet Genomics. 2016 Aug 20;43(8):481-94
pubmed: 27569398
JCI Insight. 2017 Apr 6;2(7):e90443
pubmed: 28405612
RNA Biol. 2014;11(6):673-81
pubmed: 24823351
Annu Rev Biochem. 2010;79:803-33
pubmed: 20196649
Science. 2004 Apr 30;304(5671):734-6
pubmed: 15118162
RNA Biol. 2017 Jan 2;14(1):58-72
pubmed: 27791479
Clin Chem. 2008 Mar;54(3):482-90
pubmed: 18218722
Bioinformatics. 2012 Dec 15;28(24):3211-7
pubmed: 23071270
Nature. 1963 May 11;198:549-51
pubmed: 13945312
PLoS One. 2014 Sep 05;9(9):e106006
pubmed: 25191859
FASEB J. 2017 Jul;31(7):2760-2770
pubmed: 28289056
AIDS Res Hum Retroviruses. 1993 Nov;9(11):1157-65
pubmed: 8312057
Annu Rev Nutr. 2016 Jul 17;36:301-36
pubmed: 27215587
J Cell Sci. 2011 Feb 1;124(Pt 3):447-58
pubmed: 21242314
J Extracell Vesicles. 2017 Mar 7;6(1):1286095
pubmed: 28326170
Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E587-96
pubmed: 26768848
Nature. 2004 Sep 16;431(7006):356-63
pubmed: 15372043
Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12048-53
pubmed: 23818581
J Immunol. 2010 Mar 1;184(5):2369-76
pubmed: 20130213
Placenta. 2016 Nov;47:86-95
pubmed: 27780544
Blood. 2004 Nov 15;104(10):3257-66
pubmed: 15284116
J Gen Virol. 1993 Jan;74 ( Pt 1):129-35
pubmed: 8093711
Front Immunol. 2016 Aug 31;7:335
pubmed: 27630638
Development. 2005 Nov;132(21):4653-62
pubmed: 16224045
Virology. 1997 Mar 31;230(1):125-33
pubmed: 9126268
PLoS One. 2012;7(3):e31952
pubmed: 22470417
Science. 2010 Jun 18;328(5985):1563-6
pubmed: 20558719
J Virol. 2010 May;84(10):5229-37
pubmed: 20219912
Traffic. 2008 Sep;9(10):1728-42
pubmed: 18637904
J Biol Chem. 2016 Apr 1;291(14):7221-8
pubmed: 26887954
Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):279-84
pubmed: 22184245
J Innate Immun. 2017;9(6):574-586
pubmed: 28877527
Front Genet. 2018 Oct 02;9:439
pubmed: 30333857
J Biol Chem. 2008 Dec 26;283(52):36211-20
pubmed: 18984593
ACS Nano. 2015 Mar 24;9(3):2321-7
pubmed: 25672598
Semin Cell Dev Biol. 2017 Jul;67:48-55
pubmed: 28104520
J Virol. 2011 Mar;85(5):2439-48
pubmed: 21177825
Mol Cell. 2014 Apr 10;54(1):67-79
pubmed: 24725595
Nucleic Acids Res. 2016 May 19;44(9):4340-53
pubmed: 26984525
Mol Ther. 2013 Feb;21(2):368-79
pubmed: 23183536
Curr Opin Immunol. 2018 Oct;54:109-114
pubmed: 30015086
BMC Genomics. 2017 Jun 30;18(1):502
pubmed: 28666407
J Biol Chem. 2009 Dec 4;284(49):34211-22
pubmed: 19801663
J Extracell Vesicles. 2015 Mar 26;4:26373
pubmed: 25819213
Bioinformatics. 2012 Feb 1;28(3):433-5
pubmed: 22155869
Cell Rep. 2018 Dec 18;25(12):3356-3370.e4
pubmed: 30566862
Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):941-6
pubmed: 22215596
J Biol Chem. 2013 Jul 5;288(27):20014-33
pubmed: 23661700
Science. 2005 Sep 2;309(5740):1577-81
pubmed: 16141076
J Extracell Vesicles. 2014 Dec 22;3:26913
pubmed: 25536934
Biochem Soc Trans. 2012 Aug;40(4):886-90
pubmed: 22817753
Nat Genet. 2005 Jul;37(7):766-70
pubmed: 15965474
Nat Protoc. 2016 Jan;11(1):87-101
pubmed: 26658469
Blood. 2005 Sep 1;106(5):1604-11
pubmed: 15741221
PLoS Pathog. 2014 Feb 06;10(2):e1003865
pubmed: 24516379
Nat Rev Microbiol. 2017 Sep;15(9):559-572
pubmed: 28649136
J Control Release. 2017 Nov 28;266:100-108
pubmed: 28919558
Immunology. 1978 Jan;34(1):123-9
pubmed: 75176
Curr Protoc Cell Biol. 2006 Apr;Chapter 3:Unit 3.22
pubmed: 18228490
Nat Commun. 2013;4:2980
pubmed: 24356509
Nucleic Acids Res. 2018 Sep 28;46(17):9081-9093
pubmed: 29893896
Cell. 2013 Apr 25;153(3):562-74
pubmed: 23622241
PLoS Pathog. 2017 Sep 14;13(9):e1006611
pubmed: 28910400
PLoS Pathog. 2012 Feb;8(2):e1002510
pubmed: 22346748
Nature. 2015 Nov 19;527(7578):329-35
pubmed: 26524530
J Cell Physiol. 1972 Feb;79(1):147-50
pubmed: 4333154
PLoS Pathog. 2014 Oct 02;10(10):e1004424
pubmed: 25275643
PLoS One. 2016 Mar 10;11(3):e0150933
pubmed: 26963812
Cell. 2012 Mar 16;148(6):1172-87
pubmed: 22424228
Nucleic Acids Res. 2015 Jun 23;43(11):5601-16
pubmed: 25940616
Expert Opin Biol Ther. 2011 Jan;11(1):17-29
pubmed: 21133815
J Hepatol. 2014 Mar;60(3):674-5
pubmed: 24512825
Nat Commun. 2018 Feb 26;9(1):831
pubmed: 29483512
J Extracell Vesicles. 2013 Sep 12;2:
pubmed: 24223256
Nat Commun. 2014 Sep 16;5:4816
pubmed: 25226414
J Virol. 2015 Nov;89(21):10901-11
pubmed: 26292323
Cell. 2017 Jul 13;170(2):352-366.e13
pubmed: 28709002
Br J Haematol. 2008 May;141(5):672-5
pubmed: 18318758
J Biol Chem. 2013 Jun 14;288(24):17713-24
pubmed: 23653359
Nat Genet. 2006 Jun;38 Suppl:S25-30
pubmed: 16736021
Retrovirology. 2018 Jul 3;15(1):45
pubmed: 29970099
J Virol. 2017 Feb 28;91(6):
pubmed: 28077652
Oncoimmunology. 2015 Mar 19;4(6):e1008371
pubmed: 26155418
Cell Host Microbe. 2012 Oct 18;12(4):558-70
pubmed: 23084922
Cell. 2018 Mar 22;173(1):20-51
pubmed: 29570994
Cell Rep. 2018 Jun 12;23(11):3275-3285
pubmed: 29898398
J Biol Chem. 2014 Aug 8;289(32):22284-305
pubmed: 24939845
Cell Host Microbe. 2012 Aug 16;12(2):200-10
pubmed: 22901540
J Virol. 2017 Jan 18;91(3):
pubmed: 27852859
PLoS One. 2015 Jul 10;10(7):e0131787
pubmed: 26161560
mBio. 2016 Feb 09;7(1):e02025-15
pubmed: 26861021
Nature. 2002 Jul 11;418(6894):244-51
pubmed: 12110901
BMC Cancer. 2011 Mar 27;11:108
pubmed: 21439085
Nat Cell Biol. 2007 Jun;9(6):654-9
pubmed: 17486113
Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6328-33
pubmed: 20304794
Retrovirology. 2009 Feb 16;6:18
pubmed: 19220914
Exp Cell Res. 1971 Apr;65(2):313-24
pubmed: 4101797
J Gen Virol. 2014 Jun;95(Pt 6):1307-1319
pubmed: 24668525
Nat Commun. 2014;5:3344
pubmed: 24561744
J Extracell Vesicles. 2018 Dec 12;8(1):1552059
pubmed: 30559953
Trends Mol Med. 2017 Jan;23(1):80-93
pubmed: 27989642
J Virol. 1999 Feb;73(2):1460-7
pubmed: 9882352
J Clin Invest. 2013 May;123(5):1902-10
pubmed: 23635788
Front Microbiol. 2017 May 15;8:824
pubmed: 28555130
Sci Rep. 2016 Aug 09;6:31175
pubmed: 27503761
Cell Rep. 2014 Sep 25;8(6):1649-1658
pubmed: 25242326
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E968-77
pubmed: 26858453
J Virol. 1984 Nov;52(2):396-402
pubmed: 6492255
J Extracell Vesicles. 2017 Jan 12;6(1):1272832
pubmed: 28326168
Cell Res. 2011 Jan;21(1):159-68
pubmed: 21187858
J Proteome Res. 2013 May 3;12(5):2045-54
pubmed: 23432411
Cancer Cell. 2016 Dec 12;30(6):836-848
pubmed: 27960084
J Extracell Vesicles. 2014 Mar 25;3:
pubmed: 24678387
PLoS Pathog. 2012 Dec;8(12):e1003018
pubmed: 23308061
Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10205-10
pubmed: 17551004
Sci Rep. 2015 Jun 03;5:10300
pubmed: 26036864
Cell. 2005 Jan 14;120(1):15-20
pubmed: 15652477
Trends Immunol. 2009 Jan;30(1):1-7
pubmed: 19059006
J Extracell Vesicles. 2015 May 14;4:27066
pubmed: 25979354
J Mol Cell Biol. 2014 Apr;6(2):172-4
pubmed: 24380870
J Cell Biol. 2016 Apr 25;213(2):173-84
pubmed: 27114500
PLoS Biol. 2005 Mar;3(3):e85
pubmed: 15723116
Nat Commun. 2017 Oct 26;8(1):1145
pubmed: 29074968
Cell. 2003 Dec 26;115(7):787-98
pubmed: 14697198
Cell Res. 2008 Oct;18(10):997-1006
pubmed: 18766170
J Gen Virol. 2015 Apr;96(Pt 4):739-751
pubmed: 25406174
Cell Rep. 2016 May 3;15(5):978-987
pubmed: 27117408
BMC Genomics. 2015 Mar 05;16:151
pubmed: 25764986
Virology. 1997 Mar 31;230(1):134-44
pubmed: 9126269
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Nat Rev Mol Cell Biol. 2014 Aug;15(8):509-24
pubmed: 25027649
J Infect Dis. 2019 Jan 29;219(4):540-543
pubmed: 30239899
Eur J Immunol. 2004 Oct;34(10):2834-42
pubmed: 15368299
Semin Immunopathol. 2018 Sep;40(5):491-504
pubmed: 29789863
Front Immunol. 2014 Oct 29;5:542
pubmed: 25400635
Front Mol Biosci. 2017 Nov 28;4:79
pubmed: 29234666
Nature. 2005 Jun 2;435(7042):682-6
pubmed: 15931223
PLoS One. 2017 Apr 25;12(4):e0176458
pubmed: 28441451
RNA Biol. 2013 Feb;10(2):169-74
pubmed: 23296026
Science. 1999 Oct 29;286(5441):950-2
pubmed: 10542148
Annu Rev Pathol. 2017 Jan 24;12:153-186
pubmed: 27959632
Cell. 2007 Aug 10;130(3):413-26
pubmed: 17693253
BMC Gastroenterol. 2015 May 27;15:63
pubmed: 26013123
Int J Mol Sci. 2018 Nov 09;19(11):
pubmed: 30423996
J Extracell Vesicles. 2014 Sep 30;3:
pubmed: 25317276
Cell Host Microbe. 2013 Oct 16;14(4):435-45
pubmed: 24075860
Traffic. 2010 May;11(5):675-87
pubmed: 20136776
J Biol Chem. 2014 Aug 8;289(32):22258-67
pubmed: 24951588
J Infect. 2013 Oct;67(4):329-41
pubmed: 23685241
Nucleic Acids Res. 2012 Jan;40(1):414-27
pubmed: 21911362
Microbiol Mol Biol Rev. 2016 Mar 02;80(2):369-86
pubmed: 26935137
PLoS Pathog. 2017 Aug 24;13(8):e1006524
pubmed: 28837697
Sci Rep. 2018 Jan 10;8(1):387
pubmed: 29321591
Cell. 2015 May 21;161(5):1046-1057
pubmed: 26000481
Annu Rev Cell Dev Biol. 2014;30:255-89
pubmed: 25288114
J Virol. 2008 Aug;82(16):7812-7
pubmed: 18524834
Methods Mol Biol. 2018;1740:69-83
pubmed: 29388137
Blood. 2011 Jan 27;117(4):e39-48
pubmed: 21041717
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8
pubmed: 18663219
Front Immunol. 2015 May 04;6:203
pubmed: 25999947
EMBO Rep. 2015 Jan;16(1):24-43
pubmed: 25488940
Sci Rep. 2015 Jan 08;5:7675
pubmed: 25567797
Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13109-13
pubmed: 23878230
Medicine (Baltimore). 2016 Jan;95(2):e2511
pubmed: 26765470
Biomed Res Int. 2018 Jan 30;2018:8545347
pubmed: 29662902
Front Microbiol. 2017 Apr 21;8:689
pubmed: 28484438
Int J Mol Sci. 2017 Mar 20;18(3):
pubmed: 28335522
Genes Dev. 2015 Mar 15;29(6):567-84
pubmed: 25792595
Genes Dev. 2009 Nov 15;23(22):2639-49
pubmed: 19933153
Virus Genes. 2016 Apr;52(2):189-94
pubmed: 26837894
Mol Hum Reprod. 2012 Aug;18(8):417-24
pubmed: 22383544
Cancer Res. 1978 Oct;38(10):3546-54
pubmed: 688240
Philos Trans R Soc Lond B Biol Sci. 2009 Jan 12;364(1513):99-115
pubmed: 18926973
J Biol Chem. 2016 Jan 15;291(3):1251-66
pubmed: 26553869
FASEB J. 2016 Dec;30(12):4132-4140
pubmed: 27605546
BMC Mol Biol. 2007 Jul 30;8:63
pubmed: 17663774
Cell Mol Life Sci. 2018 Oct;75(20):3857-3875
pubmed: 29808415
Nucleic Acids Res. 2008 Apr;36(7):2353-65
pubmed: 18299284
J Virol. 2014 Apr;88(7):3612-22
pubmed: 24403582
J Infect Dis. 2018 Apr 11;217(9):1372-1382
pubmed: 29373693
Nature. 2014 Feb 13;506(7487):245-8
pubmed: 24352241