Primed histone demethylation regulates shoot regenerative competency.
Arabidopsis
/ physiology
Arabidopsis Proteins
/ genetics
Demethylation
Epigenesis, Genetic
/ physiology
Gene Expression Regulation, Plant
/ physiology
Histone Code
/ physiology
Histone Demethylases
/ genetics
Histones
/ metabolism
Plant Cells
/ physiology
Plant Shoots
/ cytology
Plants, Genetically Modified
Protein Processing, Post-Translational
/ physiology
Regeneration
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
16 04 2019
16 04 2019
Historique:
received:
08
08
2018
accepted:
07
03
2019
entrez:
18
4
2019
pubmed:
18
4
2019
medline:
29
5
2019
Statut:
epublish
Résumé
Acquisition of pluripotency by somatic cells is a striking process that enables multicellular organisms to regenerate organs. This process includes silencing of genes to erase original tissue memory and priming of additional cell type specification genes, which are then poised for activation by external signal inputs. Here, through analysis of genome-wide histone modifications and gene expression profiles, we show that a gene priming mechanism involving LYSINE-SPECIFIC DEMETHYLASE 1-LIKE 3 (LDL3) specifically eliminates H3K4me2 during formation of the intermediate pluripotent cell mass known as callus derived from Arabidopsis root cells. While LDL3-mediated H3K4me2 removal does not immediately affect gene expression, it does facilitate the later activation of genes that act to form shoot progenitors when external cues lead to shoot induction. These results give insights into the role of H3K4 methylation in plants, and into the primed state that provides plant cells with high regenerative competency.
Identifiants
pubmed: 30992430
doi: 10.1038/s41467-019-09386-5
pii: 10.1038/s41467-019-09386-5
pmc: PMC6467990
doi:
Substances chimiques
Arabidopsis Proteins
0
Histones
0
Histone Demethylases
EC 1.14.11.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1786Références
Genome Biol. 2009;10(6):R62
pubmed: 19508735
PLoS Genet. 2012 Aug;8(8):e1002911
pubmed: 22927830
Plant J. 2002 Feb;29(3):347-58
pubmed: 11844111
Nature. 2005 Sep 15;437(7057):432-5
pubmed: 16079794
Bioessays. 2012 Mar;34(3):194-204
pubmed: 22247014
EMBO J. 2008 Oct 8;27(19):2523-32
pubmed: 18650936
Development. 2016 May 1;143(9):1442-51
pubmed: 27143753
Bioessays. 2005 Dec;27(12):1286-93
pubmed: 16299767
Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12377-82
pubmed: 17640912
Regeneration (Oxf). 2017 Feb 01;4(1):15-20
pubmed: 28316791
Nature. 2017 Nov 2;551(7678):124-128
pubmed: 29072296
Dev Biol. 2007 Mar 1;303(1):259-69
pubmed: 17224141
Mol Cell Biol. 2014 Jun;34(12):2308-17
pubmed: 24732800
Epigenetics. 2009 Jul 1;4(5):302-6
pubmed: 19633430
Genes Dev. 2009 Dec 15;23(24):2824-38
pubmed: 20008934
Genome Biol. 2009;10(3):R25
pubmed: 19261174
Plant J. 1998 Dec;16(6):735-43
pubmed: 10069079
Plant Cell. 2017 Feb;29(2):409-422
pubmed: 28188265
Cell. 2004 Dec 29;119(7):941-53
pubmed: 15620353
Science. 2017 Mar 31;355(6332):
pubmed: 28360266
Biochemistry. 2008 Apr 29;47(17):4936-47
pubmed: 18393445
Nature. 2013 Oct 24;502(7472):462-71
pubmed: 24153299
Plant J. 2007 Oct;52(2):223-39
pubmed: 17922773
Nat Plants. 2016 Oct 31;2(11):16165
pubmed: 27797356
Cell Mol Biol (Noisy-le-grand). 2014 Dec 24;60(5):97-105
pubmed: 25535719
Mol Cell Biol. 2010 Jul;30(13):3342-56
pubmed: 20439496
Cell. 2009 Sep 18;138(6):1184-94
pubmed: 19766570
Curr Biol. 2015 Apr 20;25(8):1017-30
pubmed: 25819565
Development. 2007 Oct;134(19):3539-48
pubmed: 17827180
BMC Genomics. 2014 Apr 15;15:284
pubmed: 24735413
Proc Natl Acad Sci U S A. 1988 Aug;85(15):5536-40
pubmed: 16593964
Curr Opin Genet Dev. 2011 Apr;21(2):140-6
pubmed: 21316216
Trends Cell Biol. 2011 Apr;21(4):212-8
pubmed: 21236679
Cell Res. 2011 Mar;21(3):381-95
pubmed: 21321607
Nature. 2005 Sep 15;437(7057):436-9
pubmed: 16079795
Curr Opin Plant Biol. 2018 Feb;41:23-31
pubmed: 28843861
Plant J. 2003 Sep;35(6):729-42
pubmed: 12969426
Curr Opin Plant Biol. 2019 Feb;47:138-150
pubmed: 30703741
Nat Genet. 2011 Jun 05;43(7):715-9
pubmed: 21642989
Plant Cell. 2017 May;29(5):1073-1087
pubmed: 28389585
Nat Genet. 2009 Jan;41(1):125-9
pubmed: 19098913
Plant Sci. 2015 Sep;238:251-61
pubmed: 26259192
EMBO Rep. 2015 Dec;16(12):1620-39
pubmed: 26564907
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Cell. 2007 May 18;129(4):823-37
pubmed: 17512414
EMBO J. 2017 Apr 13;36(8):970-980
pubmed: 28100676
Nat Rev Mol Cell Biol. 2016 Mar;17(3):139-54
pubmed: 26883001
Genome Biol. 2008;9(9):R137
pubmed: 18798982
Plant Physiol. 1992 May;99(1):263-8
pubmed: 16668860
Cell. 2017 Sep 21;171(1):34-57
pubmed: 28938122
Plant J. 2009 Feb;57(4):626-44
pubmed: 18980654
Dev Cell. 2010 Mar 16;18(3):463-71
pubmed: 20230752
Cell Stem Cell. 2010 Jul 2;7(1):114-26
pubmed: 20621055
EMBO Rep. 2015 Dec;16(12):1609-19
pubmed: 26553936
EMBO J. 2010 Oct 20;29(20):3496-506
pubmed: 20834229
Development. 2007 Feb;134(4):635-46
pubmed: 17215298
Science. 2003 Dec 5;302(5651):1751-4
pubmed: 14593187
Nat Biotechnol. 2011 Jan;29(1):24-6
pubmed: 21221095
Biochim Biophys Acta. 2013 Oct;1829(10):981-6
pubmed: 23684752
Planta. 2007 Oct;226(5):1183-94
pubmed: 17581762
Cell. 2007 Nov 16;131(4):633-6
pubmed: 18022353
PLoS Genet. 2011 Aug;7(8):e1002243
pubmed: 21876682
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Dev Biol. 2018 Oct 1;442(1):13-27
pubmed: 29709600
Cell. 2000 Mar 17;100(6):635-44
pubmed: 10761929
Science. 2014 Jan 31;343(6170):1248559
pubmed: 24482483
Plant Cell. 2007 Oct;19(10):2975-87
pubmed: 17921315
Mol Cell Biol. 2010 Oct;30(20):4851-63
pubmed: 20713442
Bioinformatics. 2010 Mar 15;26(6):841-2
pubmed: 20110278
Curr Opin Plant Biol. 2016 Dec;34:41-53
pubmed: 27614255