Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials.

Acetylcholinesterase / metabolism Acinetobacter baumannii / drug effects Anti-Bacterial Agents / chemical synthesis Carbonic Anhydrase I / antagonists & inhibitors Carbonic Anhydrase II / antagonists & inhibitors Cholinergic Antagonists / chemical synthesis Dose-Response Relationship, Drug Enzyme Inhibitors / chemical synthesis Escherichia coli / drug effects Eugenol / chemical synthesis Glycoside Hydrolases / antagonists & inhibitors Hypoglycemic Agents / chemical synthesis Microbial Sensitivity Tests Molecular Structure Propanolamines / chemical synthesis Pseudomonas aeruginosa / drug effects Staphylococcus aureus / drug effects Structure-Activity Relationship

Acetylcholinesterase Antibacterial effects Carbonic anhydrase Enzyme inhibition Eugenol α-glycosidase

Journal

Bioorganic chemistry

ISSN: 1090-2120

Titre abrégé: Bioorg Chem

Pays: United States

ID NLM: 1303703

Informations de publication

Date de publication:
07 2019

Historique:

received: 28 08 2018

revised: 27 03 2019

accepted: 15 04 2019

pubmed: 25 4 2019

medline: 23 9 2020

entrez: 25 4 2019

Statut: ppublish

Résumé

Five oxypropanol amine derivatives that four of them are novel have been synthesized with high yields and practical methods. in vitro antibacterial susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus strains to synthesized substances were evaluated with agar well-diffusion method by comparison with commercially available drugs. Most of the bacteria were multidrug resistant. It was concluded that these compounds are much more effective than reference drugs. These eugenol bearing oxypropanolamine derivatives were also effective inhibitors against α-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) enzymes with K

Identifiants

DOI: 10.1016/j.bioorg.2019.102931 PMID: 31015178

pubmed: 31015178

pii: S0045-2068(18)30950-7

doi: 10.1016/j.bioorg.2019.102931

pii:

doi:

Substances chimiques

Anti-Bacterial Agents 0

Cholinergic Antagonists 0

Enzyme Inhibitors 0

Hypoglycemic Agents 0

Propanolamines 0

oxypropanolamine 0

Eugenol 3T8H1794QW

Acetylcholinesterase EC 3.1.1.7

Glycoside Hydrolases EC 3.2.1.-

Carbonic Anhydrase I EC 4.2.1.-

Carbonic Anhydrase II EC 4.2.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

102931

Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials.

Journal

Informations de publication

Résumé

Identifiants

Substances chimiques

Types de publication

Langues

Sous-ensembles de citation

Pagination

Informations de copyright

Auteurs

Hayriye Genç Bilgiçli (H)

Ali Kestane (A)

Parham Taslimi (P)

Oguz Karabay (O)

Arlinda Bytyqi-Damoni (A)

Mustafa Zengin (M)

İlhami Gulçin (İ)

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Classifications MeSH