Expression and role of regulator of G-protein signaling 5 in squamous cell carcinoma of the tongue.
Aged
Aged, 80 and over
Antigens, CD
/ metabolism
Cadherins
/ metabolism
Epithelial-Mesenchymal Transition
Female
Head and Neck Neoplasms
/ metabolism
Humans
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Invasiveness
RGS Proteins
/ metabolism
Squamous Cell Carcinoma of Head and Neck
/ metabolism
Tongue Neoplasms
/ metabolism
Tumor Burden
Vimentin
/ metabolism
RGS5
immunohistochemical staining
oral cancer
tongue
Journal
Clinical and experimental dental research
ISSN: 2057-4347
Titre abrégé: Clin Exp Dent Res
Pays: United States
ID NLM: 101692332
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
26
10
2018
revised:
03
12
2018
accepted:
04
12
2018
entrez:
4
5
2019
pubmed:
3
5
2019
medline:
3
5
2019
Statut:
epublish
Résumé
Regulator of G-protein signaling (RGS) 5 acts as a GTPase-activating protein to negatively regulate G-protein signaling. RGS5 is reportedly related to the invasion and metastasis of cancers, such as nonsmall lung cancer and hepatocellular carcinoma. We examined RGS5 expression and its relationship with invasion in squamous cell carcinoma (SCC) of the tongue. For immunohistochemical analysis of RGS5, we used SCC tissues of the tongue obtained from 43 patients. We examined the relationship between RGS5 expression in the deepest point of invasion and clinicopathological features. Because the invasion and metastasis of cancers are related to epithelial-mesenchymal transition (EMT), we carried out staining for N-cadherin, vimentin, and E-cadherin to examine the relationship between EMT and RGS5. RGS5 expression in the deepest point of invasion in SCC of the tongue was observed in 32 cases (75%). Immunohistochemical analysis revealed a significant correlation between RGS5 expression in the aggressive invasion pattern, invasion depth, and lymphovascular invasion. Kaplan-Meier analysis revealed that high RGS5 expression was associated with postoperative early lymph node metastasis. Further, a significant positive correlation was observed between RGS5 and N-cadherin (
Identifiants
pubmed: 31049219
doi: 10.1002/cre2.166
pii: CRE2166
pmc: PMC6483038
doi:
Substances chimiques
Antigens, CD
0
CDH1 protein, human
0
CDH2 protein, human
0
Cadherins
0
RGS Proteins
0
RGS5 protein, human
0
VIM protein, human
0
Vimentin
0
Types de publication
Journal Article
Langues
eng
Pagination
160-169Déclaration de conflit d'intérêts
The authors have no conflict of interest.
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