Extended delivery of non-steroidal anti-inflammatory drugs through contact lenses loaded with Vitamin E and cationic surfactants.
Anti-Inflammatory Agents, Non-Steroidal
/ pharmacokinetics
Contact Lenses, Hydrophilic
Delayed-Action Preparations
Diclofenac
/ pharmacokinetics
Drug Delivery Systems
/ instrumentation
Fatty Alcohols
/ chemistry
Flurbiprofen
/ pharmacokinetics
Ketorolac Tromethamine
/ pharmacokinetics
Quaternary Ammonium Compounds
/ chemistry
Surface-Active Agents
/ chemistry
Vitamin E
/ chemistry
Cationic surfactant
Contact lenses
Drug delivery
NSAID
Vitamin E
Journal
Contact lens & anterior eye : the journal of the British Contact Lens Association
ISSN: 1476-5411
Titre abrégé: Cont Lens Anterior Eye
Pays: England
ID NLM: 9712714
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
07
12
2018
revised:
08
04
2019
accepted:
09
04
2019
pubmed:
16
5
2019
medline:
21
10
2020
entrez:
16
5
2019
Statut:
ppublish
Résumé
The purpose of this study is to extend drug release from ACUVUE Oasys® and ACUVUE TruEye® silicone hydrogel contact lenses by incorporation of vitamin E in conjunction with a cationic surfactant. In ACUVUE Oasys® and ACUVUE TruEye®, the release of ketorolac tromethamine and flurbiprofen sodium is extended from hours to several days for 11% and 21% vitamin E, (weight of vitamin E / weight of dry lens) but with a considerable reduction in the amount of drug released. Cetalkonium chloride and stearylamine increased the drug loading capacity which was otherwise compromised by the addition of vitamin E in the contact lenses. In the case of diclofenac sodium, a sustained release over 150 h for both contact lenses can be achieved. It was found that the release-time-increase factor due to vitamin E has a linear dependence with the octanol-water partition coefficient of the drug in ACUVUE Oasys®. The results in this study show that contact lenses loaded with vitamin E in conjunction with cationic surfactants achieved sustained release of non-steroidal anti-inflammatory drugs (NSAIDs) within the therapeutic window.
Identifiants
pubmed: 31085116
pii: S1367-0484(18)31036-1
doi: 10.1016/j.clae.2019.04.011
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Delayed-Action Preparations
0
Fatty Alcohols
0
Quaternary Ammonium Compounds
0
Surface-Active Agents
0
Vitamin E
1406-18-4
Diclofenac
144O8QL0L1
Ketorolac Tromethamine
4EVE5946BQ
Flurbiprofen
5GRO578KLP
cetalkonium chloride
85474O1N9D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
546-552Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.