Genetic architecture of maize chlorotic mottle virus and maize lethal necrosis through GWAS, linkage analysis and genomic prediction in tropical maize germplasm.
Journal
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
ISSN: 1432-2242
Titre abrégé: Theor Appl Genet
Pays: Germany
ID NLM: 0145600
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
04
12
2018
accepted:
08
05
2019
pubmed:
18
5
2019
medline:
21
12
2019
entrez:
18
5
2019
Statut:
ppublish
Résumé
Analysis of the genetic architecture of MCMV and MLN resistance in maize doubled-haploid populations revealed QTLs with major effects on chromosomes 3 and 6 that were consistent across genetic backgrounds and environments. Two major-effect QTLs, qMCMV3-108/qMLN3-108 and qMCMV6-17/qMLN6-17, were identified as conferring resistance to both MCMV and MLN. Maize lethal necrosis (MLN) is a serious threat to the food security of maize-growing smallholders in sub-Saharan Africa. The ability of the maize chlorotic mottle virus (MCMV) to interact with other members of the Potyviridae causes severe yield losses in the form of MLN. The objective of the present study was to gain insights and validate the genetic architecture of resistance to MCMV and MLN in maize. We applied linkage mapping to three doubled-haploid populations and a genome-wide association study (GWAS) on 380 diverse maize lines. For all the populations, phenotypic variation for MCMV and MLN was significant, and heritability was moderate to high. Linkage mapping revealed 13 quantitative trait loci (QTLs) for MCMV resistance and 12 QTLs conferring MLN resistance. One major-effect QTL, qMCMV3-108/qMLN3-108, was consistent across populations for both MCMV and MLN resistance. Joint linkage association mapping (JLAM) revealed 18 and 21 main-effect QTLs for MCMV and MLN resistance, respectively. Another major-effect QTL, qMCMV6-17/qMLN6-17, was detected for both MCMV and MLN resistance. The GWAS revealed a total of 54 SNPs (MCMV-13 and MLN-41) significantly associated (P ≤ 5.60 × 10
Identifiants
pubmed: 31098757
doi: 10.1007/s00122-019-03360-x
pii: 10.1007/s00122-019-03360-x
pmc: PMC6647133
doi:
Substances chimiques
maize chlorotic mottle virus
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2381-2399Subventions
Organisme : Bill and Melinda Gates Foundation
ID : OPP1134248
Références
G3 (Bethesda). 2013 Feb;3(2):197-203
pubmed: 23390596
BMC Plant Biol. 2015 Aug 20;15:206
pubmed: 26289207
Phytopathology. 2015 Jul;105(7):956-65
pubmed: 25822185
Theor Appl Genet. 2016 Jun;129(6):1217-29
pubmed: 26971113
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11479-84
pubmed: 11562485
G3 (Bethesda). 2013 Nov 06;3(11):2095-104
pubmed: 24048647
Theor Appl Genet. 2011 Sep;123(5):847-58
pubmed: 21681489
Genetics. 2001 Apr;157(4):1819-29
pubmed: 11290733
Theor Appl Genet. 2015 Oct;128(10):1957-68
pubmed: 26152570
Plant Dis. 2007 Feb;91(2):185-190
pubmed: 30781002
Curr Opin Plant Biol. 2007 Apr;10(2):156-61
pubmed: 17291822
PLoS One. 2015 Dec 21;10(12):e0145549
pubmed: 26689370
Theor Appl Genet. 2012 Mar;124(4):769-76
pubmed: 22075809
Euphytica. 2017;213(9):224
pubmed: 32009665
BMC Plant Biol. 2013 Oct 18;13:162
pubmed: 24134222
Annu Rev Virol. 2018 Sep 29;5(1):301-322
pubmed: 30059641
PLoS One. 2011 May 04;6(5):e19379
pubmed: 21573248
Bioinformatics. 2007 Oct 1;23(19):2633-5
pubmed: 17586829
G3 (Bethesda). 2016 Dec 7;6(12):3803-3815
pubmed: 27742723
Nat Genet. 2011 Feb;43(2):163-8
pubmed: 21217757
Front Plant Sci. 2017 Nov 08;8:1916
pubmed: 29167677
Curr Opin Biotechnol. 2006 Apr;17(2):155-60
pubmed: 16504497
Plant Dis. 2014 Dec;98(12):1748
pubmed: 30703919
PLoS One. 2014 Feb 28;9(2):e90346
pubmed: 24587335
Arch Virol. 2008;153(5):995-7
pubmed: 18365127
BMC Genomics. 2016 Nov 21;17(1):946
pubmed: 27871222
Theor Appl Genet. 2014 Apr;127(4):867-80
pubmed: 24500307
Sci Rep. 2018 Jan 19;8(1):1173
pubmed: 29352173
Plant Genome. 2017 Jul;10(2):
pubmed: 28724072
Heredity (Edinb). 2012 Mar;108(3):332-40
pubmed: 21878984
Ann Bot. 2002 Jun;89 Spec No:941-63
pubmed: 12102519
Plant Dis. 2014 Oct;98(10):1448
pubmed: 30703969
New Phytol. 2011 Mar;189(4):909-922
pubmed: 21182529
Phytopathology. 1999 Aug;89(8):660-7
pubmed: 18944678
Heredity (Edinb). 2010 Sep;105(3):257-67
pubmed: 20461101
Genetics. 2013 Jun;194(2):493-503
pubmed: 23535384
Phytopathology. 2018 Jun;108(6):748-758
pubmed: 29287150
Nat Genet. 2006 Aug;38(8):904-9
pubmed: 16862161
Theor Popul Biol. 1988 Feb;33(1):54-78
pubmed: 3376052
BMC Genomics. 2015 Nov 10;16:916
pubmed: 26555731
PLoS One. 2015 Oct 21;10(10):e0140617
pubmed: 26488483
Mol Breed. 2018;38(5):66
pubmed: 29773962
Heredity (Edinb). 2014 Jan;112(1):48-60
pubmed: 23572121
PLoS One. 2015 Nov 03;10(11):e0142001
pubmed: 26529245
J Anim Breed Genet. 2007 Dec;124(6):331-41
pubmed: 18076470
Plant Cell. 2001 Jul;13(7):1527-40
pubmed: 11449049
Plant J. 2005 Dec;44(6):1054-64
pubmed: 16359397
Plant Physiol. 2015 Dec;169(4):2950-62
pubmed: 26432875
Plant Sci. 2012 Nov;196:125-31
pubmed: 23017907
Genetics. 2000 Apr;154(3):1839-1849
pubmed: 10866652
Sci Rep. 2017 Jan 06;7:39960
pubmed: 28059116
Mol Genet Genomics. 2005 Jul;273(6):450-61
pubmed: 15891912
Plant Dis. 2012 Oct;96(10):1582
pubmed: 30727337