Carbon catabolite repression: not only for glucose.

Acetic Acid / metabolism Alcohol Dehydrogenase / metabolism Catabolite Repression Ethanol / metabolism Gene Expression Regulation, Fungal Glucose / metabolism Glycerol / metabolism Saccharomyces cerevisiae / genetics Saccharomyces cerevisiae Proteins / metabolism
Acetic acid Glycerol Saccharomyces cerevisiae Yeast

Journal

Current genetics
ISSN: 1432-0983
Titre abrégé: Curr Genet
Pays: United States
ID NLM: 8004904

Informations de publication

Date de publication:
Dec 2019
Historique:
received: 28 04 2019
accepted: 14 05 2019
revised: 28 04 2019
pubmed: 24 5 2019
medline: 14 4 2020
entrez: 24 5 2019
Statut: ppublish

Résumé

Most organisms prefer to utilize glucose as a carbon source. Accordingly, the expression of genes involved in the catabolism of other carbon sources is repressed by the presence of glucose in a process known as (carbon) catabolite repression. However, much less is known about the relationships between "poor" carbon sources. We have recently shown that the enzyme alcohol dehydrogenase of the yeast Saccharomyces cerevisiae (ADH2), required for the utilization of ethanol, is not only inhibited by glucose, but by the acetate imported from the medium or produced by ethanol metabolism. Our study showed that sensing of acetate takes place within the cell, and not in the external medium, and that "poor" carbon sources are also utilized according to a pre-established hierarchy.

Identifiants

DOI: 10.1007/s00294-019-00996-6 PMID: 31119370
pubmed: 31119370
doi: 10.1007/s00294-019-00996-6
pii: 10.1007/s00294-019-00996-6
doi:

Substances chimiques

Saccharomyces cerevisiae Proteins 0
Ethanol 3K9958V90M
ADH2 protein, S cerevisiae EC 1.1.1.1
Alcohol Dehydrogenase EC 1.1.1.1
Glucose IY9XDZ35W2
Glycerol PDC6A3C0OX
Acetic Acid Q40Q9N063P

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1321-1323

Subventions

Organisme : Israel Science Foundation
ID : 0
Organisme : Minerva Center
ID : 0

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Auteurs

Kobi Simpson-Lavy (K)

School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat Aviv, 69978, Tel Aviv, Israel.

Martin Kupiec (M)

School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Ramat Aviv, 69978, Tel Aviv, Israel. martin@post.tau.ac.il.
ORCID: 0000-0002-7934-3342

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Classifications MeSH

questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Acétates › Acide acétique › Carbon catabolite repression: not only for glucose.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Alcohol dehydrogenase › Carbon catabolite repression: not only for glucose.
questionsmedicales.fr › Phénomènes microbiologiques › Répression catabolique › Carbon catabolite repression: not only for glucose.
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Carbon catabolite repression: not only for glucose.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes fongiques › Carbon catabolite repression: not only for glucose.
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Carbon catabolite repression: not only for glucose.
questionsmedicales.fr › Glucides › Polyols › Dérivés du glycérol › Glycérol › Carbon catabolite repression: not only for glucose.
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Carbon catabolite repression: not only for glucose.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Carbon catabolite repression: not only for glucose.