Systems analysis reveals complex biological processes during virus infection fate decisions.
Acute Disease
Animals
Biomarkers
Chronic Disease
Computational Biology
/ methods
Gene Expression Profiling
High-Throughput Nucleotide Sequencing
Host-Pathogen Interactions
/ genetics
Immunity, Cellular
Immunity, Humoral
Inflammation Mediators
/ metabolism
Mice
Models, Biological
Spleen
/ immunology
Systems Biology
/ methods
Virus Diseases
/ virology
Virus Physiological Phenomena
Journal
Genome research
ISSN: 1549-5469
Titre abrégé: Genome Res
Pays: United States
ID NLM: 9518021
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
03
07
2018
accepted:
14
05
2019
pubmed:
30
5
2019
medline:
3
1
2020
entrez:
30
5
2019
Statut:
ppublish
Résumé
The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an alleviated immune response and chronic infection are poorly understood. Here, we characterized the host response to acute and chronic lymphocytic choriomeningitis virus (LCMV) infections by gene coexpression network analysis of time-resolved splenic transcriptomes. First, we found an early attenuation of inflammatory monocyte/macrophage prior to the onset of T cell exhaustion, and second, a critical role of the XCL1-XCR1 communication axis during the functional adaptation of the T cell response to the chronic infection state. These findings not only reveal an important feedback mechanism that couples T cell exhaustion with the maintenance of a lower level of effector T cell response but also suggest therapy options to better control virus levels during the chronic infection phase.
Identifiants
pubmed: 31138618
pii: gr.241372.118
doi: 10.1101/gr.241372.118
pmc: PMC6581057
doi:
Substances chimiques
Biomarkers
0
Inflammation Mediators
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
907-919Informations de copyright
© 2019 Argilaguet et al.; Published by Cold Spring Harbor Laboratory Press.
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