Comparative Fluxome and Metabolome Analysis of Formate as an Auxiliary Substrate for Penicillin Production in Glucose-Limited Cultivation of Penicillium chrysogenum.
Bioreactors
/ microbiology
Formate Dehydrogenases
/ metabolism
Formates
/ metabolism
Fungal Proteins
/ metabolism
Glucose
/ metabolism
Hydrogenase
/ metabolism
Metabolomics
/ methods
Multienzyme Complexes
/ metabolism
Penicillins
/ metabolism
Penicillium chrysogenum
/ chemistry
Stress, Physiological
Penicillium chrysogenum
auxiliary substrates
chemostat
metabolomics
penicillin
Journal
Biotechnology journal
ISSN: 1860-7314
Titre abrégé: Biotechnol J
Pays: Germany
ID NLM: 101265833
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
07
01
2019
revised:
20
05
2019
pubmed:
30
5
2019
medline:
11
2
2020
entrez:
30
5
2019
Statut:
ppublish
Résumé
During glucose-limited growth, a substantial input of adenosine triphosphate (ATP) is required for the production of β-lactams by the filamentous fungus Penicillium chrysogenum. Formate dehydrogenase has been confirmed in P. chrysogenum for formate oxidation allowing an extra supply of ATP, and coassimilation of glucose and formate has the potential to increase penicillin production and biomass yield. In this study, the steady-state metabolite levels and fluxes in response to cofeeding of formate as an auxiliary substrate in glucose-limited chemostat cultures at the dilution rates (D) of both 0.03 h
Identifiants
pubmed: 31140716
doi: 10.1002/biot.201900009
doi:
Substances chimiques
Formates
0
Fungal Proteins
0
Multienzyme Complexes
0
Penicillins
0
formic acid
0YIW783RG1
Hydrogenase
EC 1.12.7.2
Formate Dehydrogenases
EC 1.17.1.9
formate hydrogenlyase
EC 1.17.1.9
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900009Subventions
Organisme : the 111 Project
ID : B18022
Organisme : National key research and development program
ID : 2017ZX7402003
Organisme : the Fundamental Research Funds for the Central Universities
ID : 22221818014
Organisme : NWO-MoST Joint Program
ID : 2013DFG32630
Organisme : National Key Research and Development Program
ID : 2017ZX7402003
Organisme : 111 Project (B18022)
Organisme : Fundamental Research Funds for the Central Universities
ID : 22221818014
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.