Circulating Tumor DNA as a Clinical Test in Resected Pancreatic Cancer.
Aged
Aged, 80 and over
Biomarkers, Tumor
Carcinoma, Pancreatic Ductal
/ diagnosis
Circulating Tumor DNA
Female
Genetic Testing
/ methods
High-Throughput Nucleotide Sequencing
Humans
Liquid Biopsy
/ methods
Male
Middle Aged
Mutation
Neoplasm Staging
Pancreatic Neoplasms
/ diagnosis
Prognosis
Proto-Oncogene Proteins p21(ras)
/ genetics
Recurrence
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 08 2019
15 08 2019
Historique:
received:
17
01
2019
revised:
15
04
2019
accepted:
23
05
2019
pubmed:
31
5
2019
medline:
20
8
2020
entrez:
31
5
2019
Statut:
ppublish
Résumé
In research settings, circulating tumor DNA (ctDNA) shows promise as a tumor-specific biomarker for pancreatic ductal adenocarcinoma (PDAC). This study aims to perform analytical and clinical validation of a Digital-droplet PCR was used to detect the major PDAC-associated somatic ctDNA was detected preoperatively in 29 (49%) patients and was an independent predictor of decreased recurrence-free survival (RFS) and overall survival (OS). Patients who had neoadjuvant chemotherapy were less likely to have preoperative ctDNA than were chemo-naïve patients (21% vs. 69%; Measurement of
Identifiants
pubmed: 31142500
pii: 1078-0432.CCR-19-0197
doi: 10.1158/1078-0432.CCR-19-0197
pmc: PMC7403524
mid: NIHMS1609811
doi:
Substances chimiques
Biomarkers, Tumor
0
Circulating Tumor DNA
0
KRAS protein, human
0
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4973-4984Subventions
Organisme : NCI NIH HHS
ID : P30 CA006973
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA062924
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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