Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers.
MAPT
MRS
converter
frontotemporal lobar degeneration
longitudinal
Journal
Journal of neuroimaging : official journal of the American Society of Neuroimaging
ISSN: 1552-6569
Titre abrégé: J Neuroimaging
Pays: United States
ID NLM: 9102705
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
25
02
2019
revised:
16
04
2019
accepted:
22
05
2019
pubmed:
8
6
2019
medline:
20
6
2020
entrez:
8
6
2019
Statut:
ppublish
Résumé
The objective of this study was to longitudinally investigate the trajectory of change in We identified eight MAPT mutations carriers who transitioned from asymptomatic to symptomatic disease during follow-up. All participants were longitudinally followed with an average of 7.75 years (range 4-11 years) and underwent two or more single voxel The decrease in the NAA/mI ratio accelerated 2.09 years prior to symptom onset, and continued to decline. A similar trajectory was observed in the presumed glial marker mI/Cr ratio accelerating 1.86 years prior to symptom onset. Our findings support the potential use of longitudinal
Sections du résumé
BACKGROUND AND PURPOSE
The objective of this study was to longitudinally investigate the trajectory of change in
METHODS
We identified eight MAPT mutations carriers who transitioned from asymptomatic to symptomatic disease during follow-up. All participants were longitudinally followed with an average of 7.75 years (range 4-11 years) and underwent two or more single voxel
RESULTS
The decrease in the NAA/mI ratio accelerated 2.09 years prior to symptom onset, and continued to decline. A similar trajectory was observed in the presumed glial marker mI/Cr ratio accelerating 1.86 years prior to symptom onset.
CONCLUSIONS
Our findings support the potential use of longitudinal
Identifiants
pubmed: 31173437
doi: 10.1111/jon.12642
pmc: PMC6731148
mid: NIHMS1031842
doi:
Substances chimiques
Biomarkers
0
MAPT protein, human
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
624-629Subventions
Organisme : NIA NIH HHS
ID : K24 AG045333
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016574
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS097261
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG040042
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG063911
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG045390
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS092089
Pays : United States
Informations de copyright
© 2019 The Authors. Journal of Neuroimaging published by Wiley Periodicals, Inc. on behalf of American Society of Neuroimaging.
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