Tubes for detection of cholinesterase inhibitors-Unique effects of Neusilin on the stability of butyrylcholinesterase-impregnated carriers.


Journal

Enzyme and microbial technology
ISSN: 1879-0909
Titre abrégé: Enzyme Microb Technol
Pays: United States
ID NLM: 8003761

Informations de publication

Date de publication:
Sep 2019
Historique:
received: 05 03 2019
revised: 03 05 2019
accepted: 04 05 2019
entrez: 13 6 2019
pubmed: 13 6 2019
medline: 9 11 2019
Statut: ppublish

Résumé

Detection tubes are small devices for the colorimetric enzymatic detection of cholinesterase inhibitors such as sarin, soman, VX nerve agents and substances denoted as Novichok. These detectors contain carriers in the form of pellets with immobilized cholinesterase, substrate and detection reagent. Their advantages are portability, sensitivity and simplicity, enabling fast detection of such compounds from air and water in case of a terrorist attack or war. In general, maintaining the stability of an enzyme for a longer time is very problematic; therefore, its further enhancement is required for safety and financial reasons. In this study, the stability of our patented carriers in the form of pellets with immobilized butyrylcholinesterase containing an increasing amount of the unique sorbent Neusilin

Identifiants

pubmed: 31186107
pii: S0141-0229(19)30069-9
doi: 10.1016/j.enzmictec.2019.05.002
pii:
doi:

Substances chimiques

Aluminum Compounds 0
Cholinesterase Inhibitors 0
Drug Carriers 0
Enzymes, Immobilized 0
Magnesium Compounds 0
Silicates 0
aluminum magnesium silicate 6M3P64V0NC
Butyrylcholinesterase EC 3.1.1.8

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

26-33

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Jiří Zeman (J)

Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.

David Vetchý (D)

Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic. Electronic address: vetchy@email.cz.

Sylvie Pavloková (S)

Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.

Aleš Franc (A)

Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.

Vladimír Pitschmann (V)

Oritest Ltd., Prague, Czech Republic; Faculty of Biomedical Engineering, Czech Technical University, Kladno, Czech Republic.

Martin Dominik (M)

Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.

Martina Urbanová (M)

Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic.

Ivana Šeděnková (I)

Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic.

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Classifications MeSH