Synthesis of oxadiazole-coupled-thiadiazole derivatives as a potent β-glucuronidase inhibitors and their molecular docking study.

Glycoproteins / pharmacology Molecular Docking Simulation / methods Oxadiazoles / chemical synthesis
Molecular docking study Oxadiazole-thiadiazole SAR β-Glucuronidase inhibition

Journal

Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298

Informations de publication

Date de publication:
15 07 2019
Historique:
received: 09 01 2019
revised: 16 05 2019
accepted: 31 05 2019
pubmed: 15 6 2019
medline: 10 9 2020
entrez: 15 6 2019
Statut: ppublish

Résumé

A new series of oxadiazole with thiadiazole moiety (6-27) were synthesized, characterized by different spectroscopic techniques and evaluated for β-glucuronidase inhibitory potential. Sixteen analogs such as 6, 7, 8, 9, 10, 12, 13, 14, 17, 18, 20, 23, 24, 25, 26 and 27 showed IC

Identifiants

DOI: 10.1016/j.bmc.2019.05.049 PMID: 31196753
pubmed: 31196753
pii: S0968-0896(19)30212-3
doi: 10.1016/j.bmc.2019.05.049
pii:
doi:

Substances chimiques

Glycoproteins 0
Oxadiazoles 0
beta-glucuronidase inhibitor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3145-3155

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Muhammad Taha (M)

Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia. Electronic address: mtaha@iau.edu.sa.

Syahrul Imran (S)

Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor D. E., Malaysia.

Munther Alomari (M)

Department of Stem Cell Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P. O. Box. 1982, Dammam 31441, Saudi Arabia.

Fazal Rahim (F)

Department of Chemistry, Hazara University, Mansehra 21120, Pakistan.

Abdul Wadood (A)

Department of Biochemistry, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan.

Ashik Mosaddik (A)

Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia.

Nizam Uddin (N)

Department of Chemistry, University of Karachi, Karachi 75270, Pakistan.

Mohammed Gollapalli (M)

Department of Computer Information Systems, College of Computer Science & Information Technology (CCSIT) Imam Abdulrahman Bin Faisal University P.O. Box 1982, Dammam 31441, Saudi Arabia.

Mohammed A Alqahtani (MA)

Department of Computer Information Systems, College of Computer Science & Information Technology (CCSIT) Imam Abdulrahman Bin Faisal University P.O. Box 1982, Dammam 31441, Saudi Arabia.

Yasser A Bamarouf (YA)

Department of Computer Information Systems, College of Computer Science & Information Technology (CCSIT) Imam Abdulrahman Bin Faisal University P.O. Box 1982, Dammam 31441, Saudi Arabia.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Synthesis of oxadiazole-coupled-thiadiazole...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Synthesis of oxadiazole-coupled-thiadiazole...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Oxazoles › Oxadiazoles › Synthesis of oxadiazole-coupled-thiadiazole...