Next-Generation Sequencing in Acute Lymphoblastic Leukemia.
Disease Management
Gene Expression Profiling
Genetic Predisposition to Disease
Genome-Wide Association Study
Genomics
/ methods
High-Throughput Nucleotide Sequencing
Humans
Oncogenes
Practice Patterns, Physicians'
Precision Medicine
/ methods
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ diagnosis
ALL
MRD
NGS
acute lymphoblastic leukemia
minimal residual disease
next-generation sequencing
precision medicine
targeted therapy
third generation sequencing
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Jun 2019
15 Jun 2019
Historique:
received:
21
05
2019
revised:
04
06
2019
accepted:
14
06
2019
entrez:
19
6
2019
pubmed:
19
6
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and accounts for about a quarter of adult acute leukemias, and features different outcomes depending on the age of onset. Improvements in ALL genomic analysis achieved thanks to the implementation of next-generation sequencing (NGS) have led to the recent discovery of several novel molecular entities and to a deeper understanding of the existing ones. The purpose of our review is to report the most recent discoveries obtained by NGS studies for ALL diagnosis, risk stratification, and treatment planning. We also report the first efforts at NGS use for minimal residual disease (MRD) assessment, and early studies on the application of third generation sequencing in cancer research. Lastly, we consider the need for the integration of NGS analyses in clinical practice for genomic patients profiling from the personalized medicine perspective.
Identifiants
pubmed: 31208040
pii: ijms20122929
doi: 10.3390/ijms20122929
pmc: PMC6627957
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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