COP9 Signalosome Interaction with UspA/Usp15 Deubiquitinase Controls VeA-Mediated Fungal Multicellular Development.

Active Transport, Cell Nucleus Aspergillus nidulans / cytology COP9 Signalosome Complex / metabolism Cell Nucleus / metabolism Fungal Proteins / metabolism Protein Binding Transcription, Genetic Ubiquitin-Specific Proteases / metabolism
COP9 signalosome (CSN), Aspergillus nidulans Fbx23 Usp15/UspA deubiquitination fungal development secondary metabolism ubiquitin ubiquitin-specific protease velvet domain proteins

Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
18 06 2019
Historique:
received: 02 05 2019
revised: 02 06 2019
accepted: 16 06 2019
entrez: 21 6 2019
pubmed: 21 6 2019
medline: 26 2 2020
Statut: epublish

Résumé

COP9 signalosome (CSN) and Den1/A deneddylases physically interact and promote multicellular development in fungi. CSN recognizes Skp1/cullin-1/Fbx E3 cullin-RING ligases (CRLs) without substrate and removes their posttranslational Nedd8 modification from the cullin scaffold. This results in CRL complex disassembly and allows Skp1 adaptor/Fbx receptor exchange for altered substrate specificity. We characterized the novel ubiquitin-specific protease UspA of the mold

Identifiants

DOI: 10.3390/biom9060238 PMID: 31216760 PMC: PMC6627422
pubmed: 31216760
pii: biom9060238
doi: 10.3390/biom9060238
pmc: PMC6627422
pii:
doi:

Substances chimiques

Fungal Proteins 0
COP9 Signalosome Complex EC 3.4.19.12
Ubiquitin-Specific Proteases EC 3.4.19.12

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Cindy Meister (C)

Department of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany. cmeiste@gwdg.de.

Karl G Thieme (KG)

Department of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany. kthieme@gwdg.de.

Sabine Thieme (S)

Department of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany. sreen@gwdg.de.
ORCID: 0000-0002-0853-4723

Anna M Köhler (AM)

Department of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany. akoehle3@gwdg.de.

Kerstin Schmitt (K)

Department of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany. kschmit1@gwdg.de.

Oliver Valerius (O)

Department of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany. ovaleri@gwdg.de.

Gerhard H Braus (GH)

Department of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany. gbraus@gwdg.de.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Transport biologique › Transport des protéines › Transport nucléaire actif › COP9 Signalosome Interaction with UspA/Usp15...
questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Aspergillus › Aspergillus nidulans › COP9 Signalosome Interaction with UspA/Usp15...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Ubiquitin-specific proteases › Complexe du signalosome COP9 › COP9 Signalosome Interaction with UspA/Usp15...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › COP9 Signalosome Interaction with UspA/Usp15...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › COP9 Signalosome Interaction with UspA/Usp15...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › COP9 Signalosome Interaction with UspA/Usp15...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › COP9 Signalosome Interaction with UspA/Usp15...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Ubiquitin-specific proteases › COP9 Signalosome Interaction with UspA/Usp15...