Viruses in Vietnamese Patients Presenting with Community-Acquired Sepsis of Unknown Cause.
Adolescent
Adult
Aged
Aged, 80 and over
Asian People
Child
Child, Preschool
Community-Acquired Infections
/ epidemiology
Female
High-Throughput Nucleotide Sequencing
Hospitals
Humans
Infant
Infant, Newborn
Male
Metagenomics
Middle Aged
Polymerase Chain Reaction
Retrospective Studies
Sepsis
/ epidemiology
Vietnam
/ epidemiology
Virus Diseases
/ epidemiology
Viruses
/ classification
Young Adult
Vietnam
community-acquired sepsis
viral metagenomics
Journal
Journal of clinical microbiology
ISSN: 1098-660X
Titre abrégé: J Clin Microbiol
Pays: United States
ID NLM: 7505564
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
13
03
2019
accepted:
12
06
2019
pubmed:
21
6
2019
medline:
8
7
2020
entrez:
21
6
2019
Statut:
epublish
Résumé
Community-acquired (CA) sepsis is a major public health problem worldwide, yet the etiology remains unknown for >50% of the patients. Here we applied metagenomic next-generation sequencing (mNGS) to characterize the human virome in 492 clinical samples (384 sera, 92 pooled nasal and throat swabs, 10 stools, and 6 cerebrospinal fluid samples) from 386 patients (213 adults and 173 children) presenting with CA sepsis who were recruited from 6 hospitals across Vietnam between 2013 and 2015. Specific monoplex PCRs were used subsequently to confirm the presence of viral sequences detected by mNGS. We found sequences related to 47 viral species belonging to 21 families in 358 of 386 (93%) patients, including viruses known to cause human infections. After PCR confirmation, human viruses were found in 52 of 386 patients (13.4%); picornavirus (enteroviruses [
Identifiants
pubmed: 31217274
pii: JCM.00386-19
doi: 10.1128/JCM.00386-19
pmc: PMC6711913
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105770
Pays : United States
Informations de copyright
Copyright © 2019 Anh et al.
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