The Impact of Ethinyl Estradiol on Metformin Action on Prolactin Levels in Women with Hyperprolactinemia.
Adult
Blood Glucose
/ drug effects
Case-Control Studies
Contraceptives, Oral, Hormonal
/ pharmacology
Diabetes Mellitus
/ blood
Ethinyl Estradiol
/ pharmacology
Female
Humans
Hyperprolactinemia
/ blood
Hypoglycemic Agents
/ administration & dosage
Lactotrophs
/ drug effects
Luteinizing Hormone
/ blood
Metformin
/ administration & dosage
Prediabetic State
/ blood
Prolactin
/ blood
Young Adult
Journal
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
ISSN: 1439-3646
Titre abrégé: Exp Clin Endocrinol Diabetes
Pays: Germany
ID NLM: 9505926
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
pubmed:
25
6
2019
medline:
5
10
2021
entrez:
25
6
2019
Statut:
ppublish
Résumé
Metformin reduced prolactin levels only in women with hyperprolactinemia. The purpose of this case-control study was to compare metformin action on lactoctrope function between women receiving oral contraceptive pills and women not using hormonal contraception. The study included two groups of matched women with elevated prolactin levels and new-onset prediabetes or diabetes. The first group consisted of 20 women using oral contraceptive pills for at least 12 months before entering the study, while the second group included 20 patients not using any hormonal contraception. Over the whole study period, all women were treated with metformin (1.7-3 g daily). Circulating levels of glucose, insulin, prolactin, thyrotropin, free thyroid hormones, adrenocorticotropic hormone, gonadotropins and insulin-like growth factor-1 were measured at the beginning and at the end of the study (16 weeks later). Thirty-eight patients completed the study. Metformin reduced plasma glucose levels and improved insulin sensitivity but the latter effect was stronger in women receiving oral contraceptive pills than in women not using any contraception. Although metformin treatment decreased plasma prolactin levels in both study groups, this effect was stronger in women taking oral contraceptive pills. Only in this group of women, metformin increased plasma luteinizing hormone levels. The changes in plasma prolactin correlated with their baseline insulin sensitivity and the effect of metformin on insulin sensitivity. Metformin did not affect plasma levels of thyrotropin, free thyroxine, free triiodothyronine, follicle-stimulating hormone, adrenocorticotropic hormone and insulin-like growth factor-1. The obtained results suggest that the effect of metformin on overactive lactotropes depends on estrogen levels.
Sections du résumé
BACKGROUND
BACKGROUND
Metformin reduced prolactin levels only in women with hyperprolactinemia.
OBJECTIVE
OBJECTIVE
The purpose of this case-control study was to compare metformin action on lactoctrope function between women receiving oral contraceptive pills and women not using hormonal contraception.
METHODS
METHODS
The study included two groups of matched women with elevated prolactin levels and new-onset prediabetes or diabetes. The first group consisted of 20 women using oral contraceptive pills for at least 12 months before entering the study, while the second group included 20 patients not using any hormonal contraception. Over the whole study period, all women were treated with metformin (1.7-3 g daily). Circulating levels of glucose, insulin, prolactin, thyrotropin, free thyroid hormones, adrenocorticotropic hormone, gonadotropins and insulin-like growth factor-1 were measured at the beginning and at the end of the study (16 weeks later).
RESULTS
RESULTS
Thirty-eight patients completed the study. Metformin reduced plasma glucose levels and improved insulin sensitivity but the latter effect was stronger in women receiving oral contraceptive pills than in women not using any contraception. Although metformin treatment decreased plasma prolactin levels in both study groups, this effect was stronger in women taking oral contraceptive pills. Only in this group of women, metformin increased plasma luteinizing hormone levels. The changes in plasma prolactin correlated with their baseline insulin sensitivity and the effect of metformin on insulin sensitivity. Metformin did not affect plasma levels of thyrotropin, free thyroxine, free triiodothyronine, follicle-stimulating hormone, adrenocorticotropic hormone and insulin-like growth factor-1.
CONCLUSIONS
CONCLUSIONS
The obtained results suggest that the effect of metformin on overactive lactotropes depends on estrogen levels.
Substances chimiques
Blood Glucose
0
Contraceptives, Oral, Hormonal
0
Hypoglycemic Agents
0
Ethinyl Estradiol
423D2T571U
Prolactin
9002-62-4
Luteinizing Hormone
9002-67-9
Metformin
9100L32L2N
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
22-28Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.