An unusual and vital protein with guanylate cyclase and P4-ATPase domains in a pathogenic protist.


Journal

Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869

Informations de publication

Date de publication:
06 2019
Historique:
received: 14 04 2019
revised: 06 06 2019
accepted: 06 06 2019
entrez: 26 6 2019
pubmed: 27 6 2019
medline: 27 6 2019
Statut: epublish

Résumé

cGMP signaling is one of the master regulators of diverse functions in eukaryotes; however, its architecture and functioning in protozoans remain poorly understood. Herein, we report an exclusive guanylate cyclase coupled with N-terminal P4-ATPase in a common parasitic protist,

Identifiants

pubmed: 31235476
pii: 2/3/e201900402
doi: 10.26508/lsa.201900402
pmc: PMC6592433
pii:
doi:

Substances chimiques

Protozoan Proteins 0
Adenosine Triphosphatases EC 3.6.1.-
Guanylate Cyclase EC 4.6.1.2

Banques de données

PDB
['1AZS', '1CJK']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2019 Günay-Esiyok et al.

Références

Mol Syst Biol. 2011 Oct 11;7:539
pubmed: 21988835
PLoS Pathog. 2010 Feb 05;6(2):e1000746
pubmed: 20140184
Proc Int Conf Intell Syst Mol Biol. 1998;6:175-82
pubmed: 9783223
Front Physiol. 2016 Jul 08;7:275
pubmed: 27458383
Nat Microbiol. 2019 Mar;4(3):420-428
pubmed: 30742070
Nucleic Acids Res. 2008 Jan;36(Database issue):D553-6
pubmed: 18003657
J Biol Chem. 2010 Jan 29;285(5):3282-8
pubmed: 19940133
Gene. 1999 Jul 8;234(2):239-47
pubmed: 10395896
PLoS Biol. 2014 Mar 04;12(3):e1001806
pubmed: 24594931
FEMS Microbiol Rev. 2011 May;35(3):515-41
pubmed: 21223322
J Biol Chem. 2011 May 13;286(19):17205-16
pubmed: 21454556
J Biol Chem. 2005 Oct 7;280(40):34245-58
pubmed: 16002398
Pharmacol Rev. 2000 Sep;52(3):375-414
pubmed: 10977868
PLoS Biol. 2018 Sep 12;16(9):e2005642
pubmed: 30208022
Nat Commun. 2016 Jan 22;7:10519
pubmed: 26796412
Curr Biol. 2018 Sep 10;28(17):2763-2776.e6
pubmed: 30146157
EMBO J. 2012 Dec 12;31(24):4524-34
pubmed: 23149386
Cell Signal. 2003 Dec;15(12):1081-9
pubmed: 14575863
Mol Biol Evol. 2013 Apr;30(4):772-80
pubmed: 23329690
J Cell Biol. 2004 May 10;165(3):383-93
pubmed: 15123738
Biochem J. 2001 Mar 15;354(Pt 3):697-706
pubmed: 11237875
J Biol Chem. 1997 May 2;272(18):11816-23
pubmed: 9115239
J Biol Chem. 1996 Jun 14;271(24):14010-9
pubmed: 8662859
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W327-31
pubmed: 15215404
Eukaryot Cell. 2010 Jan;9(1):37-45
pubmed: 19915077
Proc Natl Acad Sci U S A. 1998 May 12;95(10):5752-6
pubmed: 9576956
Adv Cyclic Nucleotide Res. 1981;14:315-33
pubmed: 6269385
J Biol Chem. 2016 Apr 29;291(18):9554-65
pubmed: 26933037
PLoS Pathog. 2010 Sep 09;6(9):e1001094
pubmed: 20844581
J Mol Biol. 2004 May 14;338(5):1027-36
pubmed: 15111065
Zoolog Sci. 1995 Apr;12(2):151-63
pubmed: 7580804
PLoS Biol. 2015 Nov 13;13(11):e1002288
pubmed: 26565995
IUBMB Life. 2005 Dec;57(12):797-803
pubmed: 16393782
Mol Microbiol. 2016 Oct;102(2):349-363
pubmed: 27425827
J Mol Evol. 1998 Jan;46(1):84-101
pubmed: 9419228
Physiol Rev. 1995 Oct;75(4):725-48
pubmed: 7480160
Cell Signal. 2011 Dec;23(12):1921-6
pubmed: 21914472
mBio. 2017 May 2;8(3):
pubmed: 28465425
Cell Host Microbe. 2008 Feb 14;3(2):77-87
pubmed: 18312842
Eukaryot Cell. 2009 Apr;8(4):530-9
pubmed: 19218426
Biochim Biophys Acta. 2014 Dec;1842(12 Pt B):2535-47
pubmed: 25193033
Annu Rev Biophys. 2011;40:243-66
pubmed: 21351879
Eukaryot Cell. 2009 Apr;8(4):520-9
pubmed: 19218423
Science. 1997 Dec 12;278(5345):1907-16
pubmed: 9417641
Cell Host Microbe. 2016 Mar 9;19(3):349-60
pubmed: 26962945
Eukaryot Cell. 2002 Jun;1(3):317-28
pubmed: 12455981
Mol Biochem Parasitol. 2006 Sep;149(1):86-98
pubmed: 16765465
Circ Res. 2003 Nov 28;93(11):1034-46
pubmed: 14645134
Nat Rev Microbiol. 2017 Nov;15(11):645-660
pubmed: 28867819
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12998-3003
pubmed: 19617561
Cell Discov. 2018 May 22;4:24
pubmed: 29844921
Rev Physiol Biochem Pharmacol. 2006;157:105-40
pubmed: 17236651
Bioorg Med Chem Lett. 2005 Jul 1;15(13):3296-301
pubmed: 15922595
J Protozool. 1990 Mar-Apr;37(2):133-8
pubmed: 2319489
Parasitol Res. 1993;79(5):402-8
pubmed: 8415546
J Biol Chem. 2017 Sep 15;292(37):15225-15239
pubmed: 28726641
Syst Biol. 2007 Aug;56(4):684-9
pubmed: 17661235
J Biol Chem. 2000 Jul 21;275(29):22147-56
pubmed: 10747978
J Biol Chem. 2005 Apr 22;280(16):16345-53
pubmed: 15708856
EMBO J. 2015 Mar 4;34(5):669-88
pubmed: 25595798
Cell Host Microbe. 2009 Jun 18;5(6):612-22
pubmed: 19527888
EMBO J. 1999 Aug 2;18(15):4222-32
pubmed: 10428960
PLoS One. 2014 Jun 27;9(6):e100450
pubmed: 24971596
IUBMB Life. 2004 Sep;56(9):535-40
pubmed: 15590559
EMBO J. 2017 Nov 2;36(21):3250-3267
pubmed: 29030485
J Biol Chem. 2002 May 3;277(18):15913-22
pubmed: 11834729
J Biol Chem. 2019 May 31;294(22):8959-8972
pubmed: 30992368
Microbes Infect. 2012 Aug;14(10):831-7
pubmed: 22613210
Int J Parasitol. 2004 Mar 9;34(3):369-80
pubmed: 15003497
PLoS One. 2011 Apr 25;6(4):e18390
pubmed: 21541023
Biochem J. 2005 Nov 15;392(Pt 1):221-9
pubmed: 16038615
J Cell Sci. 2011 Aug 1;124(Pt 15):2515-9
pubmed: 21768325
Open Biol. 2017 Dec;7(12):
pubmed: 29263246
Cell Host Microbe. 2018 Dec 12;24(6):804-816.e6
pubmed: 30449726
Wiley Interdiscip Rev RNA. 2018 Jan;9(1):
pubmed: 28990312
Nucleic Acids Res. 2015 Jan;43(Database issue):D257-60
pubmed: 25300481
Mol Biochem Parasitol. 2002 Apr 9;120(2):165-75
pubmed: 11897122
ACS Chem Biol. 2015 Apr 17;10(4):1145-54
pubmed: 25555060

Auteurs

Özlem Günay-Esiyok (Ö)

Institute of Biology, Faculty of Life Sciences, Humboldt University, Berlin, Germany.

Ulrike Scheib (U)

Institute of Biology, Faculty of Life Sciences, Humboldt University, Berlin, Germany.

Matthias Noll (M)

Institute of Biology, Faculty of Life Sciences, Humboldt University, Berlin, Germany.

Nishith Gupta (N)

Institute of Biology, Faculty of Life Sciences, Humboldt University, Berlin, Germany Gupta.Nishith@hu-berlin.de.

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Classifications MeSH