The multi-faceted regulation of nuclear tRNA gene transcription.
Animals
Arabidopsis
/ enzymology
Caenorhabditis elegans
/ enzymology
Cell Nucleus
/ metabolism
Chlamydomonas reinhardtii
/ enzymology
Codon
Drosophila melanogaster
Endonucleases
/ metabolism
Epigenesis, Genetic
Eukaryotic Cells
/ enzymology
Gene Expression Regulation
Genome
HEK293 Cells
Humans
Protein Conformation
RNA Polymerase II
/ metabolism
RNA Polymerase III
/ metabolism
RNA, Transfer
/ metabolism
Saccharomyces cerevisiae
/ enzymology
Sequence Analysis, RNA
Transcription, Genetic
RNA polymerase III-dependent transcription
evolution
gene expression and regulation
transfer RNAs
Journal
IUBMB life
ISSN: 1521-6551
Titre abrégé: IUBMB Life
Pays: England
ID NLM: 100888706
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
02
04
2019
accepted:
16
05
2019
pubmed:
27
6
2019
medline:
12
5
2020
entrez:
27
6
2019
Statut:
ppublish
Résumé
Transfer RNAs are among the most ancient molecules of life on earth. Beyond their crucial role in protein synthesis as carriers of amino acids, they are also important players in a plethora of other biological processes. Many debates in term of biogenesis, regulation and function persist around these fascinating non-coding RNAs. Our review focuses on the first step of their biogenesis in eukaryotes, i.e. their transcription from nuclear genes. Numerous and complementary ways have emerged during evolution to regulate transfer RNA gene transcription. Here, we will summarize the different actors implicated in this process: cis-elements, trans-factors, genomic contexts, epigenetic environments and finally three-dimensional organization of nuclear genomes. © 2019 IUBMB Life, 2019 © 2019 IUBMB Life, 71(8):1099-1108, 2019.
Substances chimiques
Codon
0
RNA, Transfer
9014-25-9
RNA Polymerase II
EC 2.7.7.-
RNA Polymerase III
EC 2.7.7.6
Endonucleases
EC 3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1099-1108Informations de copyright
© 2019 International Union of Biochemistry and Molecular Biology.