Inhibition of cyclin-dependent kinase activity exacerbates H
Blister
/ pathology
CDC2 Protein Kinase
/ antagonists & inhibitors
Cell Cycle Checkpoints
/ drug effects
Cells, Cultured
Cyclin-Dependent Kinase 2
/ antagonists & inhibitors
Cyclin-Dependent Kinases
/ antagonists & inhibitors
DNA Damage
/ drug effects
Epidermolysis Bullosa
/ pathology
Genes, Reporter
Humans
Hydrogen Peroxide
/ toxicity
Integrin beta Chains
/ metabolism
Keratinocytes
/ drug effects
Membrane Proteins
/ deficiency
Neoplasm Proteins
/ deficiency
Oxidative Stress
/ drug effects
Periodontal Diseases
/ pathology
Phosphorylation
Photosensitivity Disorders
/ pathology
Protein Binding
Protein Processing, Post-Translational
Recombinant Fusion Proteins
/ metabolism
Roscovitine
/ pharmacology
DNA damage
cell cycle
cyclin-dependent kinase 1
cyclin-dependent kinase 2
kindlin-1
Journal
Experimental dermatology
ISSN: 1600-0625
Titre abrégé: Exp Dermatol
Pays: Denmark
ID NLM: 9301549
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
25
09
2018
revised:
17
06
2019
accepted:
21
06
2019
pubmed:
2
7
2019
medline:
24
10
2020
entrez:
2
7
2019
Statut:
ppublish
Résumé
Kindler syndrome (KS) is an autosomal recessive skin disorder characterized by skin blistering and photosensitivity. KS is caused by loss of function mutations in FERMT1, which encodes Kindlin-1. Kindlin-1 is a FERM domain containing adaptor protein that is found predominantly at cell-extracellular matrix adhesions where it binds to integrin β subunits and is required for efficient integrin activation. Using keratinocytes derived from a patient with KS, into which wild-type Kindlin-1 (Kin1WT) has been expressed, we show that Kindlin-1 binds to cyclin-dependent kinase (CDK)1 and CDK2. CDK1 and CDK2 are key regulators of cell cycle progression, however, cell cycle analysis showed only small differences between the KS and KS-Kin1WT keratinocytes. In contrast, G2/M cell cycle arrest in response to oxidative stress induced by hydrogen peroxide (H
Substances chimiques
FERMT1 protein, human
0
Integrin beta Chains
0
Membrane Proteins
0
Neoplasm Proteins
0
Recombinant Fusion Proteins
0
Roscovitine
0ES1C2KQ94
Hydrogen Peroxide
BBX060AN9V
CDC2 Protein Kinase
EC 2.7.11.22
CDK1 protein, human
EC 2.7.11.22
CDK2 protein, human
EC 2.7.11.22
Cyclin-Dependent Kinase 2
EC 2.7.11.22
Cyclin-Dependent Kinases
EC 2.7.11.22
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1074-1078Subventions
Organisme : Dystrophic Epidermolysis Bullosa Research Association
ID : Brunton1
Pays : International
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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