Vac8 Controls Vacuolar Membrane Dynamics during Different Autophagy Pathways in
Vac8
autophagy
bulk autophagy
pexophagy
ribophagy
vacuole
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
30 06 2019
30 06 2019
Historique:
received:
04
05
2019
revised:
21
06
2019
accepted:
28
06
2019
entrez:
3
7
2019
pubmed:
3
7
2019
medline:
3
7
2019
Statut:
epublish
Résumé
The yeast vacuole is a vital organelle, which is required for the degradation of aberrant intracellular or extracellular substrates and the recycling of the resulting nutrients as newly available building blocks for the cellular metabolism. Like the plant vacuole or the mammalian lysosome, the yeast vacuole is the destination of biosynthetic trafficking pathways that transport the vacuolar enzymes required for its functions. Moreover, substrates destined for degradation, like extracellular endocytosed cargoes that are transported by endosomes/multivesicular bodies as well as intracellular substrates that are transported via different forms of autophagosomes, have the vacuole as destination. We found that non-selective bulk autophagy of cytosolic proteins as well as the selective autophagic degradation of peroxisomes (pexophagy) and ribosomes (ribophagy) was dependent on the armadillo repeat protein Vac8 in
Identifiants
pubmed: 31262095
pii: cells8070661
doi: 10.3390/cells8070661
pmc: PMC6678646
pii:
doi:
Substances chimiques
Saccharomyces cerevisiae Proteins
0
VAC8 protein, S cerevisiae
0
Vesicular Transport Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
Références
J Cell Sci. 1999 Nov;112 ( Pt 22):4079-87
pubmed: 10547367
J Bacteriol. 2000 Apr;182(8):2125-33
pubmed: 10735854
Mol Cell Biol. 2000 May;20(9):2984-95
pubmed: 10757783
J Biol Chem. 2000 Aug 18;275(33):25840-9
pubmed: 10837477
Mol Biol Cell. 2000 Jul;11(7):2445-57
pubmed: 10888680
Biochemistry. 2000 Nov 21;39(46):14012-8
pubmed: 11087348
EMBO J. 2001 Jun 15;20(12):3145-55
pubmed: 11406591
J Biol Chem. 2001 Sep 14;276(37):35133-40
pubmed: 11441010
Nature. 2003 Mar 6;422(6927):87-92
pubmed: 12594460
Biochem J. 2004 Nov 15;384(Pt 1):37-45
pubmed: 15283676
Mol Biol Cell. 2005 Jul;16(7):3438-53
pubmed: 15901835
Mol Biol Cell. 2005 Oct;16(10):4941-53
pubmed: 16079180
FEMS Yeast Res. 2005 Dec;5(12):1237-51
pubmed: 16183335
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17366-71
pubmed: 16301533
J Cell Sci. 2006 Jun 15;119(Pt 12):2477-85
pubmed: 16720644
J Biol Chem. 2006 Sep 15;281(37):27003-15
pubmed: 16849337
Autophagy. 2006 Oct-Dec;2(4):280-8
pubmed: 16921262
Traffic. 2006 Oct;7(10):1378-87
pubmed: 16978392
Methods. 2006 Oct;40(2):171-6
pubmed: 17012029
Mol Biol Cell. 2007 Jan;18(1):106-18
pubmed: 17079731
Science. 1991 Aug 23;253(5022):905-9
pubmed: 1715094
Biochim Biophys Acta. 2009 Apr;1793(4):650-63
pubmed: 18786576
Methods Enzymol. 2008;451:33-42
pubmed: 19185711
J Biol Chem. 2009 Jun 26;284(26):17720-30
pubmed: 19416974
Annu Rev Cell Dev Biol. 2010;26:115-36
pubmed: 20521906
Autophagy. 2010 Aug;6(6):794-7
pubmed: 20523132
Biochim Biophys Acta. 2012 Jan;1823(1):150-8
pubmed: 21963882
Biochemistry. 1990 Aug 28;29(34):7997-8002
pubmed: 2261457
Cell Logist. 2014 Jan 1;4(1):e28023
pubmed: 24843828
J Biol Chem. 1989 Jan 25;264(3):1775-8
pubmed: 2521486
Proc Natl Acad Sci U S A. 1989 Jul;86(14):5419-23
pubmed: 2568633
Biochim Biophys Acta. 2016 May;1863(5):838-49
pubmed: 26367801
Cells. 2015 Oct 05;4(4):596-621
pubmed: 26445063
Autophagy. 2016;12(1):1-222
pubmed: 26799652
Traffic. 2017 May;18(5):315-329
pubmed: 28276191
Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4539-E4548
pubmed: 28533415
Biochim Biophys Acta Mol Cell Res. 2019 Feb;1866(2):199-213
pubmed: 30408545
Trends Biochem Sci. 2019 Jun;44(6):546-554
pubmed: 30587414
Cells. 2019 Jan 02;8(1):
pubmed: 30609721
Biochem Biophys Res Commun. 1984 Oct 30;124(2):491-6
pubmed: 6541910
J Cell Biol. 1995 Nov;131(3):591-602
pubmed: 7593182
Biophys J. 1995 Feb;68(2):558-66
pubmed: 7696508
Yeast. 1994 Nov;10(11):1429-37
pubmed: 7871882
Eur J Biochem. 1994 Feb 15;220(1):19-27
pubmed: 8119286
EMBO J. 1996 Jul 1;15(13):3296-305
pubmed: 8670830
Yeast. 1996 Jul;12(9):823-32
pubmed: 8840499
Yeast. 1998 Jan 30;14(2):115-32
pubmed: 9483801
J Cell Biol. 1998 Mar 9;140(5):1063-74
pubmed: 9490720
J Cell Sci. 1998 Aug;111 ( Pt 15):2137-47
pubmed: 9664035
J Cell Sci. 1998 Oct;111 ( Pt 20):3109-18
pubmed: 9739084