Decrease in DNA methylation 1 interacts with chromomethylase and like heterochromatin protein 1 in Physcomitrella patens.
BiFC
DDM1
LHP1
chromomethylase
moss
yeast two-hybrid
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
05
06
2019
revised:
22
06
2019
accepted:
26
06
2019
pubmed:
5
7
2019
medline:
23
6
2020
entrez:
5
7
2019
Statut:
ppublish
Résumé
The nucleosome remodeling protein decrease in DNA methylation 1 (DDM1)/Lsh maintains normal levels of DNA methylation. Direct interaction between Lsh and DNA methyltransferase 1 (Dnmt1) and their localization to heterochromatin in the presence of heterochromatin protein-1α (HP1α) is a mechanism by which the concentration of DNMTs is increased at heterochromatin, and chromosome structures are stabilized in metazoans. In plants, however, it is unclear how DDM1 cooperates with methyltransferases and like heterochromatin protein 1 (LHP1). In this study, we provide evidence for a novel interaction between moss DDM1 (PpDDM1) and the chromomethylase PpCMT, that has not been reported in any plant, and between PpDDM1 and PpLHP1, that has not been reported before in any organism. Our protein-protein interaction studies may provide mechanistic insight into heterochromatin regulation.
Identifiants
pubmed: 31271647
doi: 10.1002/1873-3468.13524
doi:
Substances chimiques
Chromosomal Proteins, Non-Histone
0
Plant Proteins
0
like heterochromatin protein 1
0
DNA (Cytosine-5-)-Methyltransferases
EC 2.1.1.37
chromomethylase
EC 2.1.1.37
Banques de données
GENBANK
['XM_024545083.1', 'NP_201476.1', 'NP_003592.3', 'NP_032260.2']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2686-2697Subventions
Organisme : Science and Engineering Research Board
ID : SERB/SR/SO/PS/168/2012
Pays : International
Organisme : Guru Gobind Singh Indraprastha University
Pays : International
Organisme : Council of Scientific and Industrial Research
Pays : International
Organisme : University Grants Commission Government of India
Pays : International
Informations de copyright
© 2019 Federation of European Biochemical Societies.
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