Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling.
Aged
Aged, 80 and over
Carcinoma, Transitional Cell
/ genetics
DNA Mutational Analysis
Down-Regulation
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Kidney Neoplasms
/ genetics
Male
Microsatellite Instability
Middle Aged
Mutation
Receptor, Fibroblast Growth Factor, Type 3
/ genetics
Sequence Analysis, RNA
Signal Transduction
/ genetics
T-Lymphocytes
/ immunology
Tumor Microenvironment
/ immunology
Ureteral Neoplasms
/ genetics
Urothelium
/ pathology
Exome Sequencing
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
05 07 2019
05 07 2019
Historique:
received:
18
04
2018
accepted:
04
06
2019
entrez:
7
7
2019
pubmed:
7
7
2019
medline:
23
10
2019
Statut:
epublish
Résumé
Upper tract urothelial carcinoma (UTUC) is characterized by a distinctly aggressive clinical phenotype. To define the biological features driving this phenotype, we performed an integrated analysis of whole-exome and RNA sequencing of UTUC. Here we report several key insights from our molecular dissection of this disease: 1) Most UTUCs are luminal-papillary; 2) UTUC has a T-cell depleted immune contexture; 3) High FGFR3 expression is enriched in UTUC and correlates with its T-cell depleted immune microenvironment; 4) Sporadic UTUC is characterized by a lower total mutational burden than urothelial carcinoma of the bladder. Our findings lay the foundation for a deeper understanding of UTUC biology and provide a rationale for the development of UTUC-specific treatment strategies.
Identifiants
pubmed: 31278255
doi: 10.1038/s41467-019-10873-y
pii: 10.1038/s41467-019-10873-y
pmc: PMC6611775
doi:
Substances chimiques
FGFR3 protein, human
EC 2.7.10.1
Receptor, Fibroblast Growth Factor, Type 3
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2977Commentaires et corrections
Type : CommentIn
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