Palladium-Catalyzed Suzuki-Miyaura Reactions of Aspartic Acid Derived Phenyl Esters.
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
19 07 2019
19 07 2019
Historique:
pubmed:
11
7
2019
medline:
21
7
2020
entrez:
11
7
2019
Statut:
ppublish
Résumé
Transition-metal-catalyzed transformations of amino acids and peptides could provide a powerful method for their site-selective modification. Here, we report non-decarbonylative Pd-catalyzed Suzuki-Miyaura reactions of phenyl ester derivatives of aspartic acid to form aryl-amino ketones. These products are potentially important in the synthesis of pharmaceuticals, and our methodology represents a new route to access molecules of this type.
Identifiants
pubmed: 31290674
doi: 10.1021/acs.orglett.9b02214
pmc: PMC6939165
mid: NIHMS1063187
doi:
Substances chimiques
Esters
0
Ketones
0
Aspartic Acid
30KYC7MIAI
Palladium
5TWQ1V240M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
5762-5766Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM120162
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM132092
Pays : United States
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