Study of Gene Expression Profiles of Breast Cancers in Indian Women.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 07 2019
10 07 2019
Historique:
received:
19
09
2017
accepted:
25
06
2019
entrez:
12
7
2019
pubmed:
12
7
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Breast cancer is the most common cancer among women globally. In India, the incidence of breast cancer has increased significantly during the last two decades with a higher proportion of the disease at a young age compared to the west. To understand the molecular processes underlying breast cancer in Indian women, we analysed gene expression profiles of 29 tumours and 9 controls using microarray. In the present study, we obtained 2413 differentially expressed genes, consisting of overexpressed genes such as COL10A1, COL11A1, MMP1, MMP13, MMP11, GJB2, and CST1 and underexpressed genes such as PLIN1, FABP4, LIPE, AQP7, LEP, ADH1A, ADH1B, and CIDEC. The deregulated pathways include cell cycle, focal adhesion and metastasis, DNA replication, PPAR signaling, and lipid metabolism. Using PAM50 classifier, we demonstrated the existence of molecular subtypes in Indian women. In addition, qPCR validation of expression of metalloproteinase genes, MMP1, MMP3, MMP11, MMP13, MMP14, ADAMTS1, and ADAMTS5 showed concordance with that of the microarray data; wherein we found a significant association of ADAMTS5 down-regulation with older age (≥55 years) of patients. Together, this study reports gene expression profiles of breast tumours from the Indian subcontinent, throwing light on the pathways and genes associated with the breast tumourigenesis in Indian women.
Identifiants
pubmed: 31292488
doi: 10.1038/s41598-019-46261-1
pii: 10.1038/s41598-019-46261-1
pmc: PMC6620270
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10018Références
World J Surg Oncol. 2016 Nov 29;14(1):297
pubmed: 27894325
Int J Cancer. 1995 Jul 17;62(2):138-44
pubmed: 7622286
Oncol Rep. 2016 Jul;36(1):43-8
pubmed: 27177292
Oncol Rep. 2014 Mar;31(3):1116-20
pubmed: 24425381
PLoS One. 2015 Apr 07;10(4):e0122333
pubmed: 25848952
PLoS One. 2008 Jan 02;3(1):e1373
pubmed: 18167534
Gastric Cancer. 2019 Mar;22(2):287-301
pubmed: 30105548
Yonsei Med J. 2011 May;52(3):445-53
pubmed: 21488187
BMC Cancer. 2013 Jan 02;13:1
pubmed: 23282137
PLoS One. 2016 Apr 14;11(4):e0153411
pubmed: 27078887
Am J Cancer Res. 2014 Dec 15;5(1):52-71
pubmed: 25628920
Int J Cancer. 2015 Mar 1;136(5):E359-86
pubmed: 25220842
N Engl J Med. 1986 Aug 28;315(9):559-63
pubmed: 3736639
PLoS One. 2011 Mar 14;6(3):e17149
pubmed: 21423795
Biochim Biophys Acta. 2010 Jan;1803(1):3-19
pubmed: 19631700
Mol Med Rep. 2016 Jun;13(6):5283-9
pubmed: 27121567
Nucleic Acids Res. 2000 Sep 15;28(18):3442-4
pubmed: 10982861
Int J Oncol. 2016 May;48(5):1783-93
pubmed: 26892540
BMC Cancer. 2009 Jun 16;9:188
pubmed: 19531263
Cancer Res. 2012 Sep 1;72(17):4574-86
pubmed: 22751464
Anticancer Res. 2015 Apr;35(4):1861-6
pubmed: 25862839
J Clin Oncol. 2011 Jan 1;29(1):e18-20
pubmed: 21115855
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8418-23
pubmed: 12829800
Genomics. 2002 Feb;79(2):266-70
pubmed: 11829497
Lancet Oncol. 2013 Sep;14(10):e417-24
pubmed: 23993386
Med J Armed Forces India. 2015 Jul;71(3):254-8
pubmed: 26288493
Life Sci. 2017 Feb 1;170:41-49
pubmed: 27923621
Indian J Med Res. 2012 Jun;135(6):843-52
pubmed: 22825604
Eur J Med Res. 2013 Oct 04;18:37
pubmed: 24093889
PLoS One. 2015 Aug 19;10(8):e0136246
pubmed: 26287798
BMC Cancer. 2015 Jun 18;15:473
pubmed: 26084486
Virchows Arch. 2014 Jun;464(6):701-7
pubmed: 24756216
Lung. 2015 Aug;193(4):583-92
pubmed: 25851596
Oncotarget. 2016 Aug 23;7(34):54488-54502
pubmed: 27359054
Carcinogenesis. 2013 Oct;34(10):2300-8
pubmed: 23740839
Mod Pathol. 2015 Jun;28(6):799-806
pubmed: 25676557
Nature. 2000 Aug 17;406(6797):747-52
pubmed: 10963602
Cold Spring Harb Perspect Biol. 2011 Dec 01;3(12):
pubmed: 21917992
Sci Rep. 2018 Jul 31;8(1):11488
pubmed: 30065265
Oncol Lett. 2018 Jan;15(1):297-303
pubmed: 29375713
Oncogenesis. 2014 Apr 21;3:e100
pubmed: 24752235
Mol Cancer. 2013 Jan 05;12:2
pubmed: 23289900
J Pathol. 2005 Jan;205(2):123-9
pubmed: 15643673
Tumour Biol. 2016 Aug;37(8):11115-26
pubmed: 26912061
Oncotarget. 2016 Jul 19;7(29):46253-46262
pubmed: 27323829
Bioinformatics. 2004 Nov 22;20(17):3246-8
pubmed: 15180930
Hum Pathol. 1999 Apr;30(4):436-42
pubmed: 10208466
Breast Cancer Res. 2012 Aug 20;14(4):R120
pubmed: 22906178
J Cancer. 2016 Jun 25;7(10):1295-310
pubmed: 27390605
Biochem Biophys Res Commun. 2017 Apr 29;486(2):285-292
pubmed: 28315334
Front Physiol. 2018 May 03;9:466
pubmed: 29773994
Mol Med Rep. 2018 Jun;17(6):8091-8100
pubmed: 29693125
Pathol Res Pract. 2017 Apr;213(4):316-321
pubmed: 28238542
Int J Oncol. 2016 Dec;49(6):2255-2264
pubmed: 27779648
Behav Brain Res. 2001 Nov 1;125(1-2):279-84
pubmed: 11682119
Tumour Biol. 2016 Feb;37(2):2193-207
pubmed: 26349752
Bioinformatics. 2016 Apr 1;32(7):1097-9
pubmed: 26607490
Cancer Med. 2018 Jun;7(6):2629-2640
pubmed: 29733540
Lancet. 2018 Sep 22;392(10152):985
pubmed: 30264708
Sci Rep. 2016 Nov 18;6:36639
pubmed: 27857161
BMC Cancer. 2008 Mar 28;8:83
pubmed: 18373849
Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt A):1940-1951
pubmed: 28456643
In Silico Biol. 2008;8(5-6):383-411
pubmed: 19374127
Am J Cancer Res. 2016 Jan 15;6(2):562-76
pubmed: 27186425
Radiol Oncol. 2013 Oct 08;47(4):319-29
pubmed: 24294176
Oncogene. 2014 Jun 26;33(26):3432-40
pubmed: 23934190
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W167-74
pubmed: 24861621
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
J Clin Oncol. 1994 May;12(5):888-94
pubmed: 8164038
Epigenetics. 2016 Dec;11(12):871-880
pubmed: 27689475
Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8
pubmed: 9843981
Asian J Surg. 2009 Oct;32(4):216-23
pubmed: 19892624
J Enzyme Inhib Med Chem. 2016;31(sup1):177-183
pubmed: 27028474
Arch Oral Biol. 2014 Nov;59(11):1155-63
pubmed: 25090271
Biol Chem. 2017 Sep 26;398(10):1151-1164
pubmed: 28755528
Semin Oncol. 2009 Jun;36(3):237-49
pubmed: 19460581
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74
pubmed: 11553815
Oncotarget. 2017 Mar 21;8(12):19389-19402
pubmed: 28038473
Cancer Causes Control. 2010 Nov;21(11):1777-85
pubmed: 20559704
Mol Med Rep. 2018 Feb;17(2):3152-3157
pubmed: 29257261
Cancer Manag Res. 2019 Feb 14;11:1503-1515
pubmed: 30863160
Cancer Res Treat. 2011 Mar;43(1):1-11
pubmed: 21509157
Sci Rep. 2016 Jun 24;6:28623
pubmed: 27340107
PLoS One. 2015 Aug 13;10(8):e0135544
pubmed: 26270045
Oncol Lett. 2016 Oct;12(4):2403-2408
pubmed: 27698806
World J Surg. 2010 Oct;34(10):2308-24
pubmed: 20607258
Dis Markers. 2007;23(3):189-96
pubmed: 17473389
Biomark Cancer. 2010 Feb 11;2:1-15
pubmed: 24179381
Oncol Lett. 2018 May;15(5):6436-6442
pubmed: 29731852
Oncotarget. 2016 Jul 26;7(30):47637-47649
pubmed: 27356745
Breast Cancer Res. 2017 Sep 12;19(1):108
pubmed: 28899409
J Clin Pathol. 2007 Aug;60(8):902-6
pubmed: 17660334
Cancer Res. 2004 Jan 15;64(2):590-8
pubmed: 14744773
Cancer. 1986 Jun 1;57(11):2217-21
pubmed: 3697919
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
Asia Pac J Clin Oncol. 2017 Aug;13(4):289-295
pubmed: 28181405
Cancer Res. 2017 Jan 15;77(2):423-433
pubmed: 28069798
Stat Appl Genet Mol Biol. 2004;3:Article3
pubmed: 16646809
Tumour Biol. 2015 Jun;36(6):4039-51
pubmed: 25916206
PLoS One. 2015 Mar 09;10(3):e0119473
pubmed: 25751270
Future Oncol. 2012 Aug;8(8):1031-40
pubmed: 22894674
Asian Pac J Cancer Prev. 2014;15(23):10339-43
pubmed: 25556472
Oncotarget. 2017 Sep 19;8(60):101309-101324
pubmed: 29254166
BMC Genomics. 2015;16 Suppl 1:S11
pubmed: 25923423
Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):4968-73
pubmed: 23479608
Chin J Cancer Res. 2011 Mar;23(1):15-20
pubmed: 23467504
BMC Genomics. 2006 Apr 27;7:96
pubmed: 16643655