Thermosensitive hybrid hydrogels for the controlled release of bioactive vancomycin in the treatment of orthopaedic implant infections.
Acrylates
/ chemistry
Anti-Bacterial Agents
/ chemistry
Delayed-Action Preparations
/ chemistry
Hyaluronic Acid
/ chemistry
Hydrogels
/ chemistry
Methacrylates
/ chemistry
Orthopedics
/ methods
Polyethylene Glycols
/ chemistry
Polymers
/ chemistry
Prostheses and Implants
/ microbiology
Prosthesis-Related Infections
/ drug therapy
Staphylococcal Infections
/ drug therapy
Staphylococcus aureus
/ drug effects
Vancomycin
/ chemistry
Controlled release
Michael addition cross-linking
Protein stability
Thermosensitive hydrogels
Vancomycin
Journal
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ISSN: 1873-3441
Titre abrégé: Eur J Pharm Biopharm
Pays: Netherlands
ID NLM: 9109778
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
06
05
2019
revised:
05
07
2019
accepted:
05
07
2019
pubmed:
12
7
2019
medline:
26
11
2019
entrez:
12
7
2019
Statut:
ppublish
Résumé
The purpose of this work was the development of antibacterial delivery systems for vancomycin, with potential application in the prevention or treatment of orthopedic implant infections. Previous studies have shown tandem thermal gelling and Michael addition cross-linking of hydrogels based on methacrylate, acrylate or vinylsulfone triblock copolymers of PEG-p(HPMAm-lac
Identifiants
pubmed: 31295503
pii: S0939-6411(19)30532-6
doi: 10.1016/j.ejpb.2019.07.006
pii:
doi:
Substances chimiques
Acrylates
0
Anti-Bacterial Agents
0
Delayed-Action Preparations
0
Hydrogels
0
Methacrylates
0
Polymers
0
Polyethylene Glycols
3WJQ0SDW1A
Vancomycin
6Q205EH1VU
Hyaluronic Acid
9004-61-9
acrylic acid
J94PBK7X8S
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
322-333Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.