Retention of paternal DNA methylome in the developing zebrafish germline.

Animals Animals, Genetically Modified DNA Methylation Embryo, Nonmammalian Embryonic Development / genetics Epigenesis, Genetic / physiology Gene Expression Profiling Gene Expression Regulation, Developmental / genetics Germ Cells / growth & development Paternal Inheritance Promoter Regions, Genetic / genetics Whole Genome Sequencing Zebrafish / genetics

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
11 07 2019
Historique:
received: 19 11 2018
accepted: 31 05 2019
entrez: 13 7 2019
pubmed: 13 7 2019
medline: 28 10 2019
Statut: epublish

Résumé

Two waves of DNA methylation reprogramming occur during mammalian embryogenesis; during preimplantation development and during primordial germ cell (PGC) formation. However, it is currently unclear how evolutionarily conserved these processes are. Here we characterise the DNA methylomes of zebrafish PGCs at four developmental stages and identify retention of paternal epigenetic memory, in stark contrast to the findings in mammals. Gene expression profiling of zebrafish PGCs at the same developmental stages revealed that the embryonic germline is defined by a small number of markers that display strong developmental stage-specificity and that are independent of DNA methylation-mediated regulation. We identified promoters that are specifically targeted by DNA methylation in somatic and germline tissues during vertebrate embryogenesis and that are frequently misregulated in human cancers. Together, these detailed methylome and transcriptome maps of the zebrafish germline provide insight into vertebrate DNA methylation reprogramming and enhance our understanding of the relationships between germline fate acquisition and oncogenesis.

Identifiants

DOI: 10.1038/s41467-019-10895-6 PMID: 31296860 PMC: PMC6624265
pubmed: 31296860
doi: 10.1038/s41467-019-10895-6
pii: 10.1038/s41467-019-10895-6
pmc: PMC6624265
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3054

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Auteurs

Ksenia Skvortsova (K)

Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, NSW, 2010, Australia.

Katsiaryna Tarbashevich (K)

Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster, Münster, 48149, Germany.

Martin Stehling (M)

Flow Cytometry Unit, Max-Planck-Institute for Molecular Biomedicine, Roentgenstraße 20, 48149, Münster, Germany.

Ryan Lister (R)

ARC CoE Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Perth, WA, 6009, Australia.
Molecular Medicine Division, Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia.
ORCID: 0000-0001-6637-7239

Manuel Irimia (M)

Centre for Genomic Regulation, The Barcelona Institute for Science and Technology, Barcelona, 08003, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, 08002, Spain.
ICREA, Barcelona, 08010, Spain.
ORCID: 0000-0002-2179-2567

Erez Raz (E)

Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster, Münster, 48149, Germany.

Ozren Bogdanovic (O)

Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, NSW, 2010, Australia. o.bogdanovic@garvan.org.au.
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2010, Australia. o.bogdanovic@garvan.org.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Retention of paternal DNA methylome in the...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Animal génétiquement modifié › Retention of paternal DNA methylome in the...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Retention of paternal DNA methylome in the...
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › Retention of paternal DNA methylome in the...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Retention of paternal DNA methylome in the...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Retention of paternal DNA methylome in the...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Retention of paternal DNA methylome in the...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › Retention of paternal DNA methylome in the...
questionsmedicales.fr › Cellules › Cellules germinales › Retention of paternal DNA methylome in the...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité paternelle › Retention of paternal DNA methylome in the...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Retention of paternal DNA methylome in the...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Retention of paternal DNA methylome in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Retention of paternal DNA methylome in the...