Effects of GIT-27NO, a NO-donating compound, on hepatic ischemia/reperfusion injury.
Animals
Antineoplastic Agents
/ pharmacology
Antioxidants
/ pharmacology
Cell Line, Tumor
Cell Survival
/ drug effects
Dimethyl Fumarate
/ pharmacology
Hep G2 Cells
Hepatocytes
/ drug effects
Humans
Hydrogen Peroxide
/ pharmacology
Liver
/ drug effects
Liver Diseases
/ drug therapy
Male
Nitric Oxide
/ metabolism
Oxadiazoles
/ pharmacology
Oxidative Stress
/ drug effects
Protective Agents
/ pharmacology
Rats
Rats, Wistar
Reperfusion Injury
/ drug therapy
HepG2 cells
hydrogen peroxide
immune-inflammation
ischemia/reperfusion injury
nitric oxide
Journal
International journal of immunopathology and pharmacology
ISSN: 2058-7384
Titre abrégé: Int J Immunopathol Pharmacol
Pays: England
ID NLM: 8911335
Informations de publication
Date de publication:
Historique:
entrez:
13
7
2019
pubmed:
13
7
2019
medline:
24
1
2020
Statut:
ppublish
Résumé
Hepatic ischemia/reperfusion injury (IRI) is a clinical condition that may lead to cellular injury and organ dysfunction that can be observed in different conditions, such as trauma, shock, liver resection, and transplantation. Moderate levels of nitric oxide (NO) produced by the endothelial isoform of the NO synthase protect against liver IRI. GIT-27NO is a NO-derivative of the toll-like receptor 4 antagonist VGX-1027 that has been shown to possess both antineoplastic and immunomodulatory properties in vitro and in vivo. In this study, we have investigated the effects of this compound in vitro, in a model of oxidative stress induced in HepG2 cells by hydrogen peroxide (H
Identifiants
pubmed: 31298048
doi: 10.1177/2058738419862736
pmc: PMC6628530
doi:
Substances chimiques
Antineoplastic Agents
0
Antioxidants
0
GIT 27NO compound
0
Oxadiazoles
0
Protective Agents
0
Nitric Oxide
31C4KY9ESH
Hydrogen Peroxide
BBX060AN9V
Dimethyl Fumarate
FO2303MNI2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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