Sporadic and endemic Burkitt lymphoma have frequent
Adolescent
Binding Sites
Burkitt Lymphoma
/ genetics
Child
Child, Preschool
DEAD-box RNA Helicases
/ genetics
DNA-Binding Proteins
/ genetics
Female
Forkhead Box Protein O1
/ genetics
Gene Frequency
Gene Knockout Techniques
High-Throughput Nucleotide Sequencing
Humans
Infant
Infant, Newborn
Kaplan-Meier Estimate
Male
Mutation
Neoplasm Staging
Nucleotide Motifs
Protein Binding
Proto-Oncogene Proteins c-akt
/ metabolism
Transcription Factors
/ genetics
Young Adult
Journal
Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425
Informations de publication
Date de publication:
23 07 2019
23 07 2019
Historique:
received:
06
12
2018
accepted:
14
04
2019
entrez:
14
7
2019
pubmed:
14
7
2019
medline:
8
7
2020
Statut:
ppublish
Résumé
FOXO1 has an oncogenic role in adult germinal center-derived lymphomas, in which mutations, predominately within the AKT recognition motif, cause nuclear retention of FOXO1, resulting in increased cell proliferation. To determine the prevalence and distribution of
Identifiants
pubmed: 31300419
pii: bloodadvances.2018029546
doi: 10.1182/bloodadvances.2018029546
pmc: PMC6650741
doi:
Substances chimiques
ARID1A protein, human
0
DNA-Binding Proteins
0
FOXO1 protein, human
0
Forkhead Box Protein O1
0
Transcription Factors
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
DDX3X protein, human
EC 3.6.1.-
DEAD-box RNA Helicases
EC 3.6.4.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2118-2127Subventions
Organisme : Blood Cancer UK
ID : 12005
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
Organisme : Cancer Research UK
Pays : United Kingdom
Informations de copyright
© 2019 by The American Society of Hematology.
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