Rational Design of Hybrid Natural Products by Utilizing the Promiscuity of an Amide Synthetase.

Amides / metabolism Bacterial Proteins / genetics Biological Products / metabolism Cyclopentanes / metabolism Escherichia coli / genetics Multigene Family Mutation Peptide Synthases / genetics Protein Engineering Streptomyces / enzymology Streptomyces lividans / enzymology Substrate Specificity

Journal

ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906

Informations de publication

Date de publication:
16 08 2019
Historique:
pubmed: 17 7 2019
medline: 4 1 2020
entrez: 17 7 2019
Statut: ppublish

Résumé

WS9326A and annimycin are produced by

Identifiants

DOI: 10.1021/acschembio.9b00351 PMID: 31310500
pubmed: 31310500
doi: 10.1021/acschembio.9b00351
doi:

Substances chimiques

Amides 0
Bacterial Proteins 0
Biological Products 0
Cyclopentanes 0
Peptide Synthases EC 6.3.2.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1793-1801

Auteurs

Jing Zhu (J)

Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences , Albert-Ludwigs University , Stefan-Meier-Str. 19 , Freiburg , Germany.

Songya Zhang (S)

Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , 1068 Xueyuan Avenue , Shenzhen , People's Republic China.

David L Zechel (DL)

Department of Chemistry , Queen's University , 90 Bader Lane, Kingston , Ontario , K7L 3N6 , Canada.

Thomas Paululat (T)

Department of Organic Chemistry , University of Siegen , Adolf-Reichwein-Str. 2 , Siegen , Germany.

Andreas Bechthold (A)

Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences , Albert-Ludwigs University , Stefan-Meier-Str. 19 , Freiburg , Germany.
ORCID: 0000-0003-3594-6851

Articles similaires

Atomic view of photosynthetic metabolite permeability pathways and confinement in synthetic carboxysome shells.

Daipayan Sarkar, Christopher Maffeo, Markus Sutter et al.
1.00
Photosynthesis Ribulose-Bisphosphate Carboxylase Carbon Dioxide Molecular Dynamics Simulation Cyanobacteria

Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses.

Megan Cole, Panayiotis Anastasiou, Claudia Lee et al.
1.00
T-Lymphocytes, Regulatory Lung Neoplasms Proto-Oncogene Proteins p21(ras) Animals Humans

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis.

Spencer D Shelton, Sara House, Luiza Martins Nascentes Melo et al.
1.00
DNA, Mitochondrial Humans Melanoma Mutation Neoplasm Metastasis

Initial pH determines the morphological characteristics and secondary metabolite production in Aspergillus terreus and Streptomyces rimosus cocultures.

Tomasz Boruta, Martyna Foryś, Weronika Pawlikowska et al.
1.00
Aspergillus Hydrogen-Ion Concentration Coculture Techniques Secondary Metabolism Streptomyces rimosus

Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amides › Rational Design of Hybrid Natural Products by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Rational Design of Hybrid Natural Products by...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Rational Design of Hybrid Natural Products by...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures alicycliques › Cyclopentanes › Rational Design of Hybrid Natural Products by...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Rational Design of Hybrid Natural Products by...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Famille multigénique › Rational Design of Hybrid Natural Products by...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Rational Design of Hybrid Natural Products by...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Carbon-nitrogen ligases › Amino-acid ligases › Rational Design of Hybrid Natural Products by...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Ingénierie des protéines › Rational Design of Hybrid Natural Products by...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Streptomycetaceae › Streptomyces › Rational Design of Hybrid Natural Products by...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Streptomycetaceae › Streptomyces › Streptomyces lividans › Rational Design of Hybrid Natural Products by...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Spécificité du substrat › Rational Design of Hybrid Natural Products by...